Long-term survival after surgical intervention for bone disease in multiple myeloma
Background - We describe the surgical treatment, outcome and long-term survival of patients with multiple myeloma (MM) in response to conventional (CC) or high-dose (HDT) chemotherapy. - Patients and methods - Eighty-four patients diagnosed with MM were recruited for the study (51 male, 33 female; m...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[February 2005]
|
| In: |
Annals of oncology
Year: 2005, Jahrgang: 16, Heft: 2, Pages: 222-227 |
| ISSN: | 1569-8041 |
| DOI: | 10.1093/annonc/mdi054 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/annonc/mdi054 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0923753419484111 
|
| Verfasserangaben: | F. Zeifang, A. Zahlten-Hinguranage, H. Goldschmidt, F. Cremer, L. Bernd, D. Sabo |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1793905207 | ||
| 003 | DE-627 | ||
| 005 | 20230427030940.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220225s2005 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/annonc/mdi054 |2 doi | |
| 035 | |a (DE-627)1793905207 | ||
| 035 | |a (DE-599)KXP1793905207 | ||
| 035 | |a (OCoLC)1341445487 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zeifang, Felix |d 1967- |e VerfasserIn |0 (DE-588)115550852 |0 (DE-627)691396760 |0 (DE-576)177384662 |4 aut | |
| 245 | 1 | 0 | |a Long-term survival after surgical intervention for bone disease in multiple myeloma |c F. Zeifang, A. Zahlten-Hinguranage, H. Goldschmidt, F. Cremer, L. Bernd, D. Sabo |
| 264 | 1 | |c [February 2005] | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.02.2022 | ||
| 520 | |a Background - We describe the surgical treatment, outcome and long-term survival of patients with multiple myeloma (MM) in response to conventional (CC) or high-dose (HDT) chemotherapy. - Patients and methods - Eighty-four patients diagnosed with MM were recruited for the study (51 male, 33 female; median age 62 years) and consecutively surgically treated in a single institution during a 12-year period. The main end point of the study was overall survival after surgery. Cox regression analysis was used to estimate the effect of factors that may predict survival. - Results - Spinal surgery was performed in 54 cases, and 30 patients were surgically treated at the extremities. The post-surgical complication rate was low (17%; 14/84 patients). The median overall survival time was 47 months. Patients receiving HDT had a longer 5-year overall survival rate than patients receiving CC (51% versus 33%). Univariate predictors of mortality included age >65 years [risk ratio (RR) 1.62; P=0.023], osteolyses in long weight-bearing bones (RR 2.23; P=0.007) and an elevated C-reactive protein level >5mg/l (RR 1.82; P=0.016); the latter remained significant as a predictor in multivariate analysis (RR 2.66; P=0.0209). - Conclusions - Given the high number of patients reaching 5-year overall survival and the low post-surgery complication rate, surgery should pursue a long-term stable reconstruction of the affected bone. | ||
| 650 | 4 | |a bone | |
| 650 | 4 | |a mortality | |
| 650 | 4 | |a multiple myeloma | |
| 650 | 4 | |a oncological surgery | |
| 700 | 1 | |a Zahlten-Hinguranage, Anita |d 1964- |e VerfasserIn |0 (DE-588)124788564 |0 (DE-627)366055585 |0 (DE-576)294502955 |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 700 | 1 | |a Cremer, Friedrich Walter |d 1967- |e VerfasserIn |0 (DE-588)115550461 |0 (DE-627)691396221 |0 (DE-576)289943752 |4 aut | |
| 700 | 1 | |a Bernd, Ludger |e VerfasserIn |0 (DE-588)1076053246 |0 (DE-627)834224860 |0 (DE-576)170380513 |4 aut | |
| 700 | 1 | |a Sabo, Desiderius |e VerfasserIn |0 (DE-588)113036671 |0 (DE-627)624912698 |0 (DE-576)169206343 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of oncology |d Amsterdam [u.a.] : Elsevier, 1990 |g 16(2005), 2 vom: Feb., Seite 222-227 |h Online-Ressource |w (DE-627)320428796 |w (DE-600)2003498-2 |w (DE-576)098134345 |x 1569-8041 |7 nnas |a Long-term survival after surgical intervention for bone disease in multiple myeloma |
| 773 | 1 | 8 | |g volume:16 |g year:2005 |g number:2 |g month:02 |g pages:222-227 |g extent:6 |a Long-term survival after surgical intervention for bone disease in multiple myeloma |
| 856 | 4 | 0 | |u https://doi.org/10.1093/annonc/mdi054 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0923753419484111 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220225 | ||
| 993 | |a Article | ||
| 994 | |a 2005 | ||
| 998 | |g 113036671 |a Sabo, Desiderius |m 113036671:Sabo, Desiderius |d 910000 |d 911460 |e 910000PS113036671 |e 911460PS113036671 |k 0/910000/ |k 1/910000/911460/ |p 6 |y j | ||
| 998 | |g 1076053246 |a Bernd, Ludger |m 1076053246:Bernd, Ludger |d 910000 |d 911460 |e 910000PB1076053246 |e 911460PB1076053246 |k 0/910000/ |k 1/910000/911460/ |p 5 | ||
| 998 | |g 115550461 |a Cremer, Friedrich Walter |m 115550461:Cremer, Friedrich Walter |d 910000 |d 910100 |e 910000PC115550461 |e 910100PC115550461 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |d 50000 |e 910000PG102258023X |e 910100PG102258023X |e 50000PG102258023X |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 3 | ||
| 998 | |g 124788564 |a Zahlten-Hinguranage, Anita |m 124788564:Zahlten-Hinguranage, Anita |d 910000 |d 911460 |e 910000PZ124788564 |e 911460PZ124788564 |k 0/910000/ |k 1/910000/911460/ |p 2 | ||
| 998 | |g 115550852 |a Zeifang, Felix |m 115550852:Zeifang, Felix |d 910000 |d 911460 |e 910000PZ115550852 |e 911460PZ115550852 |k 0/910000/ |k 1/910000/911460/ |p 1 |x j | ||
| 999 | |a KXP-PPN1793905207 |e 4073292196 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Long-term survival after surgical intervention for bone disease in multiple myeloma","title":"Long-term survival after surgical intervention for bone disease in multiple myeloma"}],"origin":[{"dateIssuedKey":"2005","dateIssuedDisp":"[February 2005]"}],"note":["Gesehen am 25.02.2022"],"id":{"eki":["1793905207"],"doi":["10.1093/annonc/mdi054"]},"physDesc":[{"extent":"6 S."}],"name":{"displayForm":["F. Zeifang, A. Zahlten-Hinguranage, H. Goldschmidt, F. Cremer, L. Bernd, D. Sabo"]},"recId":"1793905207","relHost":[{"corporate":[{"display":"European Society for Medical Oncology","role":"isb"}],"language":["eng"],"part":{"volume":"16","extent":"6","pages":"222-227","year":"2005","issue":"2","text":"16(2005), 2 vom: Feb., Seite 222-227"},"title":[{"title":"Annals of oncology","subtitle":"official journal of the European Society for Medical Oncology","title_sort":"Annals of oncology"}],"pubHistory":["1.1990 -"],"note":["Gesehen am 12.11.20","Ungezählte Beil.: Supplement"],"origin":[{"publisherPlace":"Amsterdam [u.a.] ; Dordrecht [u.a.] ; Oxford","publisher":"Elsevier ; Kluwer ; Oxford Univ. Press","dateIssuedKey":"1990","dateIssuedDisp":"1990-"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Long-term survival after surgical intervention for bone disease in multiple myelomaAnnals of oncology","physDesc":[{"extent":"Online-Ressource"}],"recId":"320428796","id":{"zdb":["2003498-2"],"issn":["1569-8041"],"eki":["320428796"]}}],"person":[{"given":"Felix","role":"aut","family":"Zeifang","display":"Zeifang, Felix"},{"given":"Anita","role":"aut","family":"Zahlten-Hinguranage","display":"Zahlten-Hinguranage, Anita"},{"given":"Hartmut","role":"aut","display":"Goldschmidt, Hartmut","family":"Goldschmidt"},{"display":"Cremer, Friedrich Walter","family":"Cremer","role":"aut","given":"Friedrich Walter"},{"family":"Bernd","display":"Bernd, Ludger","role":"aut","given":"Ludger"},{"role":"aut","given":"Desiderius","display":"Sabo, Desiderius","family":"Sabo"}],"language":["eng"]} | ||
| SRT | |a ZEIFANGFELLONGTERMSU2005 | ||