Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving surgery
Purpose: Intraoperative radiotherapy (IORT) as a boost for breast cancer delivers a high single dose of radiation to a late-reacting tissue; therefore late toxicity is of particular interest, and long-term follow-up is warranted. To date there are only limited data available on breast cancer patient...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2 August 2006
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| In: |
International journal of radiation oncology, biology, physics
Year: 2006, Volume: 66, Issue: 2, Pages: 377-381 |
| ISSN: | 1879-355X |
| DOI: | 10.1016/j.ijrobp.2006.05.042 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2006.05.042
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| Author Notes: | Uta Kraus-Tiefenbacher, Lelia Bauer, Antonella Scheda, Katharina Fleckenstein, Anke Keller, Carsten Herskind, Volker Steil, Frank Melchert, Frederik Wenz |
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| 245 | 1 | 0 | |a Long-term toxicity of an intraoperative radiotherapy boost using low energy X-rays during breast-conserving surgery |c Uta Kraus-Tiefenbacher, Lelia Bauer, Antonella Scheda, Katharina Fleckenstein, Anke Keller, Carsten Herskind, Volker Steil, Frank Melchert, Frederik Wenz |
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| 520 | |a Purpose: Intraoperative radiotherapy (IORT) as a boost for breast cancer delivers a high single dose of radiation to a late-reacting tissue; therefore late toxicity is of particular interest, and long-term follow-up is warranted. To date there are only limited data available on breast cancer patients treated with IORT using low energy X-rays. We analyzed toxicity and cosmesis after IORT as a boost with a minimum follow-up of 18 months. Methods and Materials: A total of 73 patients treated with IORT (20 Gy/50 kV X-rays; INTRABEAM [Carl Zeiss Surgical, Oberkochen, Germany]) to the tumor bed during breast-conserving surgery as a boost followed by whole-breast radiotherapy (WBRT, 46 Gy) underwent a prospective, predefined follow-up (median, 25 months; range 18 44 months), including clinical examination and breast ultrasound at 6-months and mammographies at 1-year intervals. Toxicities were documented using the common toxicity criteria (CTC)/European Organization for Research and Treatment of Cancer and the LENT-SOMA score. Cosmesis was evaluated with a score from I to 4. Results: The IORT in combination with WBRT was well tolerated, with no Grade 3 or 4 skin toxicities and no telangiectasias. Fibrosis of the entire breast was observed in 5% of the patients. A circumscribed fibrosis around the tumor bed was palpable in up to 27% with a peak around 18 months after therapy and a decline thereafter. The observed toxicitiy rates were not influenced by age, tumor stage, or systemic therapy. The cosmetic outcome was good to excellent in >= 90% of cases. Conclusions: After IORT of the breast using low-energy X-rays, no unexpected toxicity rates were observed during long-term-follow-up. (c) 2006 Elsevier Inc. | ||
| 650 | 4 | |a 20-year follow-up | |
| 650 | 4 | |a boost | |
| 650 | 4 | |a brachytherapy | |
| 650 | 4 | |a breast cancer | |
| 650 | 4 | |a cancer | |
| 650 | 4 | |a cosmesis | |
| 650 | 4 | |a dose-rate | |
| 650 | 4 | |a intraoperative radiotherapy | |
| 650 | 4 | |a iort | |
| 650 | 4 | |a irradiation | |
| 650 | 4 | |a late toxicity | |
| 650 | 4 | |a lumpectomy | |
| 650 | 4 | |a radiation-therapy | |
| 650 | 4 | |a randomized trial | |
| 650 | 4 | |a recurrence | |
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