Intraoperative radiotherapy (IORT) as a boost in patients with early-stage breast cancer: acute toxicity
Background: We report on acute toxicities as well as the early cosmetic outcome of patients receiving intraoperative radiotherapy ( IORT) followed by whole-breast radiotherapy ( WBRT) compared to patients treated with standard WBRT alone. Patients and Methods: From 2/2002 until 2/2005, 84 breast can...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 14, 2006
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| In: |
Onkologie
Year: 2006, Volume: 29, Issue: 3, Pages: 77-82 |
| ISSN: | 1423-0240 |
| DOI: | 10.1159/000091160 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000091160
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| Author Notes: | Uta Kraus-Tiefenbacher, Lelia Bauer, Tanja Kehrer, Brigitte Hermann, Frank Melchert, Frederik Wenz |
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| 245 | 1 | 0 | |a Intraoperative radiotherapy (IORT) as a boost in patients with early-stage breast cancer |b acute toxicity |c Uta Kraus-Tiefenbacher, Lelia Bauer, Tanja Kehrer, Brigitte Hermann, Frank Melchert, Frederik Wenz |
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| 520 | |a Background: We report on acute toxicities as well as the early cosmetic outcome of patients receiving intraoperative radiotherapy ( IORT) followed by whole-breast radiotherapy ( WBRT) compared to patients treated with standard WBRT alone. Patients and Methods: From 2/2002 until 2/2005, 84 breast cancer patients were treated with IORT during breast-conserving surgery ( BCS) as a boost ( 20 Gy/50 kV X-rays) followed by WBRT. After wound healing, all IORT patients were treated with WBRT at a total dose of 46 Gy. For the purpose of comparison, 53 patients treated consecutively between 1/2003 and 12/2004 in our institution with BCS followed by WBRT at a total dose of 50-66 Gy, were analyzed. All patients had a defined follow-up schedule. Toxicities were prospectively documented using the CTC/EORTC Score. Cosmesis was evaluated after 6 months using a 1-4 score. Results: Treatment was well tolerated with no grade 3/4 acute toxicity. Rare adverse effects following IORT included wound healing problems ( 2%), erythema grade I-II ( 3%), palpable seroma ( 6%) and mastitis ( 2-4%). The number of patients with induration of the tumor bed was comparably low. Conclusion: IORT with the Intrabeam (TM) system applied as a boost during BCS, followed by 46 Gy WBRT, exerts similar acute toxicity as standard WBRT. Further follow-up is needed to assess long-term toxicity and efficacy. | ||
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| 650 | 4 | |a intraoperative | |
| 650 | 4 | |a irradiation | |
| 650 | 4 | |a local recurrence | |
| 650 | 4 | |a lumpectomy | |
| 650 | 4 | |a mastectomy | |
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