Exposure to type 2 diabetes provokes mitochondrial impairment in apparently healthy human hearts
Cardiac mitochondrial alterations are suspected to play a key role in the development of diabetes-related heart failure as reported in some animal and few human studies in type 2 diabetes (1). It is yet unclear whether these alterations are induced by diabetes-related metabolic changes or develop se...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
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| In: |
Diabetes care
Year: 2021, Jahrgang: 44, Heft: 5, Pages: e82-e84 |
| ISSN: | 1935-5548 |
| DOI: | 10.2337/dc20-2255 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2337/dc20-2255
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| Verfasserangaben: | Elric Zweck, Daniel Scheiber, Tomas Jelenik, Florian Bönner, Patrick Horn, Dominik Pesta, Heinz-Peter Schultheiss, Udo Boeken, Payam Akhyari, Artur Lichtenberg, Malte Kelm, Michael Roden, Ralf Westenfeld, and Julia Szendroedi |
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| 245 | 1 | 0 | |a Exposure to type 2 diabetes provokes mitochondrial impairment in apparently healthy human hearts |c Elric Zweck, Daniel Scheiber, Tomas Jelenik, Florian Bönner, Patrick Horn, Dominik Pesta, Heinz-Peter Schultheiss, Udo Boeken, Payam Akhyari, Artur Lichtenberg, Malte Kelm, Michael Roden, Ralf Westenfeld, and Julia Szendroedi |
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| 520 | |a Cardiac mitochondrial alterations are suspected to play a key role in the development of diabetes-related heart failure as reported in some animal and few human studies in type 2 diabetes (1). It is yet unclear whether these alterations are induced by diabetes-related metabolic changes or develop secondary to other factors underlying heart failure including micro- and macrovascular disease. We hypothesized that 1) exposure to type 2 diabetes provokes myocardial mitochondrial impairment prior to apparent left ventricular heart failure in humans and 2) these mitochondrial alterations are accompanied by increased oxidative stress, edema, and intracellular inflammation. | ||
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