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Exposure to type 2 diabetes provokes mitochondrial impairment in apparently healthy human hearts

Cardiac mitochondrial alterations are suspected to play a key role in the development of diabetes-related heart failure as reported in some animal and few human studies in type 2 diabetes (1). It is yet unclear whether these alterations are induced by diabetes-related metabolic changes or develop se...

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Hauptverfasser: Zweck, Elric (VerfasserIn) , Scheiber, Daniel (VerfasserIn) , Jelenik, Tomas (VerfasserIn) , Bönner, Florian (VerfasserIn) , Horn, Patrick (VerfasserIn) , Pesta, Dominik (VerfasserIn) , Schultheiss, Heinz-Peter (VerfasserIn) , Boeken, Udo (VerfasserIn) , Akhyari, Payam (VerfasserIn) , Lichtenberg, Artur (VerfasserIn) , Kelm, Malte (VerfasserIn) , Roden, Michael (VerfasserIn) , Westenfeld, Ralf (VerfasserIn) , Szendrödi, Julia (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2021
In: Diabetes care
Year: 2021, Jahrgang: 44, Heft: 5, Pages: e82-e84
ISSN:1935-5548
DOI:10.2337/dc20-2255
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2337/dc20-2255
Volltext
Verfasserangaben:Elric Zweck, Daniel Scheiber, Tomas Jelenik, Florian Bönner, Patrick Horn, Dominik Pesta, Heinz-Peter Schultheiss, Udo Boeken, Payam Akhyari, Artur Lichtenberg, Malte Kelm, Michael Roden, Ralf Westenfeld, and Julia Szendroedi
Beschreibung
Zusammenfassung:Cardiac mitochondrial alterations are suspected to play a key role in the development of diabetes-related heart failure as reported in some animal and few human studies in type 2 diabetes (1). It is yet unclear whether these alterations are induced by diabetes-related metabolic changes or develop secondary to other factors underlying heart failure including micro- and macrovascular disease. We hypothesized that 1) exposure to type 2 diabetes provokes myocardial mitochondrial impairment prior to apparent left ventricular heart failure in humans and 2) these mitochondrial alterations are accompanied by increased oxidative stress, edema, and intracellular inflammation.
Beschreibung:Gesehen am 28.02.2022
Beschreibung:Online Resource
ISSN:1935-5548
DOI:10.2337/dc20-2255

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