Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesis
Many findings support a possible involvement of a subgroup of human papillomaviruses (HPVs), called cutaneous beta HPV types, in the development of non-melanoma skin cancer. The skin of transgenic (Tg) mice expressing viral oncoproteins E6 and E7 from different cutaneous beta HPV types, including HP...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 April 2013
|
| In: |
Journal of general virology
Year: 2013, Jahrgang: 94, Heft: 4, Pages: 749-752 |
| ISSN: | 1465-2099 |
| DOI: | 10.1099/vir.0.048991-0 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1099/vir.0.048991-0 Verlag, lizenzpflichtig, Volltext: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.048991-0 
|
| Verfasserangaben: | Daniele Viarisio, Karin Müller Decker, Birgit Aengeneyndt, Christa Flechtenmacher, Lutz Gissmann and Massimo Tommasino |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1794032614 | ||
| 003 | DE-627 | ||
| 005 | 20220820135901.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220228s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1099/vir.0.048991-0 |2 doi | |
| 035 | |a (DE-627)1794032614 | ||
| 035 | |a (DE-599)KXP1794032614 | ||
| 035 | |a (OCoLC)1341445352 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Viarisio, Daniele |e VerfasserIn |0 (DE-588)1022720228 |0 (DE-627)717030717 |0 (DE-576)365832855 |4 aut | |
| 245 | 1 | 0 | |a Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesis |c Daniele Viarisio, Karin Müller Decker, Birgit Aengeneyndt, Christa Flechtenmacher, Lutz Gissmann and Massimo Tommasino |
| 264 | 1 | |c 01 April 2013 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.02.2022 | ||
| 520 | |a Many findings support a possible involvement of a subgroup of human papillomaviruses (HPVs), called cutaneous beta HPV types, in the development of non-melanoma skin cancer. The skin of transgenic (Tg) mice expressing viral oncoproteins E6 and E7 from different cutaneous beta HPV types, including HPV38, showed an increased susceptibility to UV-induced and/or chemically induced skin carcinogenesis compared with wild-type animals. In this study, we show that beta HPV38 E6 and E7 oncoproteins act as promoter and progression factors in multi-stage skin carcinogenesis, strongly cooperating with the initiator and DNA damage agent 7,12-dimethylbenz[a]anthracene. In contrast, exposure of HPV38 E6/E7 Tg mice to the promoter 12-O-tetradecanoylphorbol-13-acetate did not significantly result in the development of skin lesions. These findings further support the role of beta HPV types in skin carcinogenesis, providing additional insight into their precise contribution to the multi-step process. | ||
| 700 | 1 | |a Müller-Decker, Karin |e VerfasserIn |0 (DE-588)1084651351 |0 (DE-627)848630556 |0 (DE-576)169302431 |4 aut | |
| 700 | 1 | |a Aengeneyndt, Birgit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Flechtenmacher, Christa |e VerfasserIn |0 (DE-588)1022413147 |0 (DE-627)716965283 |0 (DE-576)365291951 |4 aut | |
| 700 | 1 | |a Gissmann, Lutz |d 1949- |e VerfasserIn |0 (DE-588)1153082020 |0 (DE-627)1014479541 |0 (DE-576)500060126 |4 aut | |
| 700 | 1 | |a Tommasino, Massimo |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of general virology |d Reading : Soc., 1967 |g 94(2013), 4, Seite 749-752 |h Online-Ressource |w (DE-627)316018058 |w (DE-600)2007065-2 |w (DE-576)090954734 |x 1465-2099 |7 nnas |a Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesis |
| 773 | 1 | 8 | |g volume:94 |g year:2013 |g number:4 |g pages:749-752 |g extent:4 |a Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesis |
| 856 | 4 | 0 | |u https://doi.org/10.1099/vir.0.048991-0 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.048991-0 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220228 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1153082020 |a Gissmann, Lutz |m 1153082020:Gissmann, Lutz |d 140000 |e 140000PG1153082020 |k 0/140000/ |p 5 | ||
| 998 | |g 1022413147 |a Flechtenmacher, Christa |m 1022413147:Flechtenmacher, Christa |d 910000 |d 912000 |e 910000PF1022413147 |e 912000PF1022413147 |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 998 | |g 1084651351 |a Müller-Decker, Karin |m 1084651351:Müller-Decker, Karin |d 140000 |e 140000PM1084651351 |k 0/140000/ |p 2 | ||
| 999 | |a KXP-PPN1794032614 |e 4075523268 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"4 S."}],"relHost":[{"id":{"zdb":["2007065-2"],"eki":["316018058"],"issn":["1465-2099"]},"origin":[{"publisher":"Soc.","dateIssuedKey":"1967","dateIssuedDisp":"1967-","publisherPlace":"Reading"}],"name":{"displayForm":["Society for General Microbiology"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Journal of general virology","subtitle":"JGV","title_sort":"Journal of general virology"}],"titleAlt":[{"title":"JGV"}],"part":{"text":"94(2013), 4, Seite 749-752","volume":"94","extent":"4","year":"2013","pages":"749-752","issue":"4"},"pubHistory":["1.1967 -"],"language":["eng"],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Society for General Microbiology","role":"isb"}],"recId":"316018058","disp":"Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesisJournal of general virology","note":["Titelzusatz ab 77.1996","Gesehen am 26.03.25"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"name":{"displayForm":["Daniele Viarisio, Karin Müller Decker, Birgit Aengeneyndt, Christa Flechtenmacher, Lutz Gissmann and Massimo Tommasino"]},"origin":[{"dateIssuedDisp":"01 April 2013","dateIssuedKey":"2013"}],"id":{"doi":["10.1099/vir.0.048991-0"],"eki":["1794032614"]},"note":["Gesehen am 28.02.2022"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1794032614","person":[{"display":"Viarisio, Daniele","roleDisplay":"VerfasserIn","role":"aut","family":"Viarisio","given":"Daniele"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Müller-Decker, Karin","given":"Karin","family":"Müller-Decker"},{"role":"aut","display":"Aengeneyndt, Birgit","roleDisplay":"VerfasserIn","given":"Birgit","family":"Aengeneyndt"},{"role":"aut","display":"Flechtenmacher, Christa","roleDisplay":"VerfasserIn","given":"Christa","family":"Flechtenmacher"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Gissmann, Lutz","given":"Lutz","family":"Gissmann"},{"roleDisplay":"VerfasserIn","display":"Tommasino, Massimo","role":"aut","family":"Tommasino","given":"Massimo"}],"title":[{"title_sort":"Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesis","title":"Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesis"}]} | ||
| SRT | |a VIARISIODAHUMANPAPIL0120 | ||