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Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method

The 388A>G and the 521T>C polymorphism of the SLCO1B1 gene affect the activity of the uptake transporter OATP1B1, thus influencing kinetics, safety, and efficacy of substrate drugs. To evaluate the impact of these polymorphisms in populations of different ethnic origins, it is important to kno...

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Main Authors: Aklillu, Eleni (Author) , Mugusi, Sabina (Author) , Ngaimisi, Eliford (Author) , Hoffmann, Michael Marcus (Author) , König, Sonja (Author) , Ziesenitz, Victoria C. (Author) , Mikus, Gerd (Author) , Haefeli, Walter E. (Author) , Weiß, Johanna (Author)
Format: Article (Journal)
Language:English
Published: 01 June 2011
In: European journal of clinical pharmacology
Year: 2011, Volume: 67, Issue: 11, Pages: 1-7
ISSN:1432-1041
DOI:10.1007/s00228-011-1065-9
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00228-011-1065-9
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Author Notes:Eleni Aklillu, Sabina Mugusi, Eliford Ngaimisi, Michael Marcus Hoffmann, Sonja König, Victoria Ziesenitz, Gerd Mikus, Walter Emil Haefeli, Johanna Weiss
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Summary:The 388A>G and the 521T>C polymorphism of the SLCO1B1 gene affect the activity of the uptake transporter OATP1B1, thus influencing kinetics, safety, and efficacy of substrate drugs. To evaluate the impact of these polymorphisms in populations of different ethnic origins, it is important to know their frequencies and to develop fast and reliable methods for genotyping. We therefore established a new, high-throughput method and determined the genotype and allelic frequencies of these polymorphisms in Tanzanians, for which the frequencies were unknown thus far.
Item Description:Gesehen am 28.02.2022
Physical Description:Online Resource
ISSN:1432-1041
DOI:10.1007/s00228-011-1065-9

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