Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer
High level microsatellite instability (MSI-H) is a hallmark of Lynch syndrome-associated colorectal cancer (CRC). MSI-H CRC express immunogenic tumour antigens as a consequence of DNA mismatch repair deficiency-induced frameshift mutations. Consequently, frameshift antigen-specific immune responses...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 May 2011
|
| In: |
Familial cancer
Year: 2011, Jahrgang: 10, Heft: 3, Pages: 557-565 |
| ISSN: | 1573-7292 |
| DOI: | 10.1007/s10689-011-9449-7 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10689-011-9449-7
|
| Verfasserangaben: | Kathrin Bauer, Sara Michel, Miriam Reuschenbach, Nina Nelius, Magnus von Knebel Doeberitz, Matthias Kloor |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1794389601 | ||
| 003 | DE-627 | ||
| 005 | 20240415193346.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220302s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10689-011-9449-7 |2 doi | |
| 035 | |a (DE-627)1794389601 | ||
| 035 | |a (DE-599)KXP1794389601 | ||
| 035 | |a (OCoLC)1341445670 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bauer, Kathrin |d 1983- |e VerfasserIn |0 (DE-588)1029200262 |0 (DE-627)732589282 |0 (DE-576)377135429 |4 aut | |
| 245 | 1 | 0 | |a Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer |c Kathrin Bauer, Sara Michel, Miriam Reuschenbach, Nina Nelius, Magnus von Knebel Doeberitz, Matthias Kloor |
| 264 | 1 | |c 20 May 2011 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.03.2022 | ||
| 520 | |a High level microsatellite instability (MSI-H) is a hallmark of Lynch syndrome-associated colorectal cancer (CRC). MSI-H CRC express immunogenic tumour antigens as a consequence of DNA mismatch repair deficiency-induced frameshift mutations. Consequently, frameshift antigen-specific immune responses are commonly observed in patients with Lynch syndrome-associated MSI-H CRC. Dendritic cells (DC) and macrophages play a crucial role in the induction and modulation of immune responses. We here analysed DC and macrophage infiltration in MSI-H and microsatellite-stable CRC. Sixty-nine CRC (MSI-H, n = 33; microsatellite-stable, n = 36) were examined for the density of tumour-infiltrating DC, Foxp3-positive regulatory T cells, and CD163-positive macrophages. In MSI-H lesions, S100-positive and CD163-positive cell counts were significantly higher compared to microsatellite-stable lesions (S100: epithelium P = 0.018, stroma P = 0.042; CD163: epithelium P < 0.001, stroma P = 0.046). Additionally, numbers of CD208-positive mature DC were significantly elevated in the epithelial compartment of MSI-H CRC (P = 0.027). High numbers of tumour-infiltrating Foxp3-positive T cells were detected in tumours showing a low proportion of CD208-positive, mature DC among the total number of S100-positive cells. Our study demonstrates that infiltration with DC, mature DC, and macrophages is elevated in MSI-H compared to microsatellite-stable CRC. The positive correlation of Foxp3-positive Treg cell density with a low proportion of mature DC suggests that impaired DC maturation may contribute to local immune evasion in CRC. Our results demonstrate that DC and macrophages in the tumour environment likely play an important role in the induction of antigen-specific immune responses in Lynch syndrome. Moreover, impaired DC maturation might contribute to local immune evasion in CRC. | ||
| 700 | 1 | |a Michel, Sara |d 1980- |e VerfasserIn |0 (DE-588)140752285 |0 (DE-627)621591270 |0 (DE-576)320635414 |4 aut | |
| 700 | 1 | |a Reuschenbach, Miriam |d 1980- |e VerfasserIn |0 (DE-588)13879734X |0 (DE-627)703109723 |0 (DE-576)309094054 |4 aut | |
| 700 | 1 | |a Nelius, Nina |e VerfasserIn |0 (DE-588)1138292184 |0 (DE-627)895606550 |0 (DE-576)492468273 |4 aut | |
| 700 | 1 | |a Knebel Doeberitz, Magnus von |e VerfasserIn |0 (DE-588)1022165291 |0 (DE-627)71693289X |0 (DE-576)364934239 |4 aut | |
| 700 | 1 | |a Kloor, Matthias |d 1972- |e VerfasserIn |0 (DE-588)124552803 |0 (DE-627)363416609 |0 (DE-576)294228616 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Familial cancer |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 2000 |g 10(2011), 3, Seite 557-565 |h Online-Ressource |w (DE-627)320528324 |w (DE-600)2015448-3 |w (DE-576)121465721 |x 1573-7292 |7 nnas |a Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer |
| 773 | 1 | 8 | |g volume:10 |g year:2011 |g number:3 |g pages:557-565 |g extent:9 |a Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10689-011-9449-7 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220302 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 124552803 |a Kloor, Matthias |m 124552803:Kloor, Matthias |d 910000 |d 912000 |e 910000PK124552803 |e 912000PK124552803 |k 0/910000/ |k 1/910000/912000/ |p 6 |y j | ||
| 998 | |g 1022165291 |a Knebel Doeberitz, Magnus von |m 1022165291:Knebel Doeberitz, Magnus von |d 910000 |d 912000 |e 910000PK1022165291 |e 912000PK1022165291 |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 998 | |g 1138292184 |a Nelius, Nina |m 1138292184:Nelius, Nina |d 910000 |d 912000 |e 910000PN1138292184 |e 912000PN1138292184 |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 998 | |g 13879734X |a Reuschenbach, Miriam |m 13879734X:Reuschenbach, Miriam |d 910000 |d 912000 |e 910000PR13879734X |e 912000PR13879734X |k 0/910000/ |k 1/910000/912000/ |p 3 | ||
| 998 | |g 140752285 |a Michel, Sara |m 140752285:Michel, Sara |d 50000 |e 50000PM140752285 |k 0/50000/ |p 2 | ||
| 998 | |g 1029200262 |a Bauer, Kathrin |m 1029200262:Bauer, Kathrin |d 50000 |e 50000PB1029200262 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1794389601 |e 4076825438 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Kathrin Bauer, Sara Michel, Miriam Reuschenbach, Nina Nelius, Magnus von Knebel Doeberitz, Matthias Kloor"]},"person":[{"roleDisplay":"VerfasserIn","family":"Bauer","display":"Bauer, Kathrin","role":"aut","given":"Kathrin"},{"family":"Michel","roleDisplay":"VerfasserIn","display":"Michel, Sara","role":"aut","given":"Sara"},{"roleDisplay":"VerfasserIn","family":"Reuschenbach","display":"Reuschenbach, Miriam","role":"aut","given":"Miriam"},{"roleDisplay":"VerfasserIn","family":"Nelius","given":"Nina","display":"Nelius, Nina","role":"aut"},{"display":"Knebel Doeberitz, Magnus von","role":"aut","given":"Magnus von","roleDisplay":"VerfasserIn","family":"Knebel Doeberitz"},{"display":"Kloor, Matthias","role":"aut","given":"Matthias","family":"Kloor","roleDisplay":"VerfasserIn"}],"physDesc":[{"extent":"9 S."}],"relHost":[{"pubHistory":["1.2000 -"],"recId":"320528324","physDesc":[{"extent":"Online-Ressource"}],"part":{"extent":"9","year":"2011","pages":"557-565","text":"10(2011), 3, Seite 557-565","volume":"10","issue":"3"},"origin":[{"publisher":"Springer Science + Business Media B.V ; Kluwer","dateIssuedDisp":"2000-","publisherPlace":"Dordrecht [u.a.] ; Dordrecht [u.a.]","dateIssuedKey":"2000"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"title":[{"title":"Familial cancer","title_sort":"Familial cancer"}],"id":{"zdb":["2015448-3"],"eki":["320528324"],"issn":["1573-7292"]},"disp":"Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancerFamilial cancer","note":["Gesehen am 02.03.05"]}],"origin":[{"dateIssuedDisp":"20 May 2011","dateIssuedKey":"2011"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"recId":"1794389601","id":{"doi":["10.1007/s10689-011-9449-7"],"eki":["1794389601"]},"title":[{"title":"Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer","title_sort":"Dendritic cell and macrophage infiltration in microsatellite-unstable and microsatellite-stable colorectal cancer"}],"note":["Gesehen am 02.03.2022"]} | ||
| SRT | |a BAUERKATHRDENDRITICC2020 | ||