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Micelle delivery of doxorubicin increases cytotoxicity to prostate carcinoma cells

The use of doxorubicin as a chemotherapeutic agent is hindered by its toxic side effects on the normal cells of the body. The objective of this study was to determine if micelle-delivered doxorubicin could increase the effectiveness of doxorubicin against prostate carcinoma cells. Rat prostate carci...

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Main Authors: McNealy, Tamara Lyn (Author) , Trojan, Lutz (Author) , Knoll, Thomas (Author) , Alken, Peter (Author) , Michel, Maurice Stephan (Author)
Format: Article (Journal)
Language:English
Published: 9 January 2004
In: Urological research
Year: 2004, Volume: 32, Issue: 4, Pages: 255-260
ISSN:1434-0879
DOI:10.1007/s00240-003-0321-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00240-003-0321-6
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Author Notes:Tamara L. McNealy, Lutz Trojan, Thomas Knoll, Peter Alken, Maurice Stephan Michel

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520 |a The use of doxorubicin as a chemotherapeutic agent is hindered by its toxic side effects on the normal cells of the body. The objective of this study was to determine if micelle-delivered doxorubicin could increase the effectiveness of doxorubicin against prostate carcinoma cells. Rat prostate carcinoma cells (MatLu) were cultured under standard conditions. Phosphate-buffered saline (PBS), doxorubicin and/or micelle solution (Pluronic 10500 solution) was added to the cell suspensions and incubated for 3 h. After incubation, cells were washed twice. Analysis consisted of: 1) immediate cell count and 2) proliferation assay at 24 and 144 h. After 24 h, samples with micelle-incorporated doxorubicin had 75% (10% pluronic with 10 µg/ml doxorubicin) and 80% (1% pluronic with 10 µg/ml doxorubicin) cell proliferation results compared with the control group. After 144-h incubation, these same two groups demonstrated cell proliferation results of only 30 and 43% of the control group. The in vitro cytotoxicity of doxorubicin against prostate carcinoma cells was dramatically increased by incorporating the molecule with polymeric micelles. 
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