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Publication rate and research topics of studies in pediatric kidney transplantation

BACKGROUND: The quality of medical care for pediatric kidney transplant recipients depends on sound evidence from published clinical trials. - METHODS: We examined the publication rate, time to publication, and factors associated with publication of studies in pediatric kidney transplantation regist...

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Hauptverfasser: Patry, Christian (VerfasserIn) , Cordts, Stephanie E. (VerfasserIn) , Baumann, Lukas (VerfasserIn) , Höcker, Britta (VerfasserIn) , Fichtner, Alexander (VerfasserIn) , Ries, Markus (VerfasserIn) , Tönshoff, Burkhard (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 07 March 2022
In: Pediatric transplantation
Year: 2022, Pages: 1-11
ISSN:1399-3046
DOI:10.1111/petr.14262
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1111/petr.14262
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Verfasserangaben:Christian Patry, Stefanie Cordts, Lukas Baumann, Britta Höcker, Alexander Fichtner, Markus Ries, Burkhard Tönshoff
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Zusammenfassung:BACKGROUND: The quality of medical care for pediatric kidney transplant recipients depends on sound evidence from published clinical trials. - METHODS: We examined the publication rate, time to publication, and factors associated with publication of studies in pediatric kidney transplantation registered on ClinicalTrials.gov from 1999 to 2020. - RESULTS: We identified 136 studies with an overall enrollment of 36255 study participants, of which only 58.8% have been published yet. Unpublished studies included data from 14 350 participants. The median time to publication was 25 months (range, 0-117) with a significantly shorter time to publication in more recent years. The most frequently investigated research topic was immunosuppressants (49.3%), followed by perioperative management (11.0%) and infectiology (10.3%). The percentage of published studies was highest for the topic steroid withdrawal (87.5%), followed by infectiology (78.6%), and nutrition, sports and quality of life (71.4%). Studies, which were co-funded by industry, showed a significantly higher 5-year publication rate (p = 0.019). - CONCLUSIONS: In conclusion, nearly half of all studies in pediatric kidney transplantation remain unpublished. Non-publication of studies might lead to a publication bias with a negative impact on clinical decision-making.
Beschreibung:Gesehen am 08.03.2022
Beschreibung:Online Resource
ISSN:1399-3046
DOI:10.1111/petr.14262

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