Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity
Nanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of extracellular matrix receptors influences collective c...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 September 2021
|
| In: |
eLife
Year: 2021, Volume: 10, Pages: 1-18 |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.69861 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.69861
|
| Author Notes: | Jacopo Di Russo, Jennifer L Young, Julian WR Wegner, Timmy Steins, Horst Kessler, Joachim P Spatz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1795146257 | ||
| 003 | DE-627 | ||
| 005 | 20230428183754.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220309s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.7554/eLife.69861 |2 doi | |
| 035 | |a (DE-627)1795146257 | ||
| 035 | |a (DE-599)KXP1795146257 | ||
| 035 | |a (OCoLC)1341445894 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Di Russo, Jacopo |d 1984- |e VerfasserIn |0 (DE-588)105982065X |0 (DE-627)798855371 |0 (DE-576)415860776 |4 aut | |
| 245 | 1 | 0 | |a Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity |c Jacopo Di Russo, Jennifer L Young, Julian WR Wegner, Timmy Steins, Horst Kessler, Joachim P Spatz |
| 246 | 3 | 3 | |a Integrin αlpha 5 beta 1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity |
| 264 | 1 | |c 23 September 2021 | |
| 300 | |a 18 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published: 23 September 2021 | ||
| 500 | |a Gesehen am 09.03.2022 | ||
| 520 | |a Nanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of extracellular matrix receptors influences collective cell migration. In wound healing, basal keratinocytes collectively migrate on a fibronectin-rich provisional basement membrane to re-epithelialize the injured skin. Among other receptors, the fibronectin receptor integrin α5β1 plays a pivotal role in this process. Using a highly specific integrin α5β1 peptidomimetic combined with nanopatterned hydrogels, we show that keratinocyte sheets regulate their migration ability at an optimal integrin α5β1 nanospacing. This efficiency relies on the effective propagation of stresses within the cell monolayer independent of substrate stiffness. For the first time, this work highlights the importance of extracellular matrix receptor nanoscale organization required for efficient tissue regeneration. | ||
| 650 | 4 | |a collective cell migration | |
| 650 | 4 | |a integrin α5β1 | |
| 650 | 4 | |a keratocytes | |
| 650 | 4 | |a wound healing | |
| 700 | 1 | |a Young, Jennifer |e VerfasserIn |0 (DE-588)1165167476 |0 (DE-627)1029328587 |0 (DE-576)510279120 |4 aut | |
| 700 | 1 | |a Wegner, Julian W. R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steins, Timmy |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kessler, Horst |d 1940- |e VerfasserIn |0 (DE-588)1168798418 |0 (DE-627)1032590394 |0 (DE-576)511744684 |4 aut | |
| 700 | 1 | |a Spatz, Joachim P. |d 1969- |e VerfasserIn |0 (DE-588)122582675 |0 (DE-627)08203124X |0 (DE-576)173014771 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t eLife |d Cambridge : eLife Sciences Publications, 2012 |g 10(2021), Artikel-ID 69861, Seite 1-18 |h Online-Ressource |w (DE-627)728518384 |w (DE-600)2687154-3 |w (DE-576)372567576 |x 2050-084X |7 nnas |a Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity |
| 773 | 1 | 8 | |g volume:10 |g year:2021 |g elocationid:69861 |g pages:1-18 |g extent:18 |a Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity |
| 856 | 4 | 0 | |u https://doi.org/10.7554/eLife.69861 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220309 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 122582675 |a Spatz, Joachim P. |m 122582675:Spatz, Joachim P. |d 120000 |d 120300 |e 120000PS122582675 |e 120300PS122582675 |k 0/120000/ |k 1/120000/120300/ |p 6 |y j | ||
| 999 | |a KXP-PPN1795146257 |e 4084859206 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Jacopo Di Russo, Jennifer L Young, Julian WR Wegner, Timmy Steins, Horst Kessler, Joachim P Spatz"]},"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"23 September 2021"}],"id":{"eki":["1795146257"],"doi":["10.7554/eLife.69861"]},"physDesc":[{"extent":"18 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["2050-084X"],"eki":["728518384"],"zdb":["2687154-3"]},"origin":[{"publisher":"eLife Sciences Publications","dateIssuedKey":"2012","dateIssuedDisp":"2012-","publisherPlace":"Cambridge"}],"part":{"text":"10(2021), Artikel-ID 69861, Seite 1-18","volume":"10","extent":"18","year":"2021","pages":"1-18"},"titleAlt":[{"title":"eLife journal"}],"pubHistory":["1.2012 -"],"language":["eng"],"recId":"728518384","disp":"Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidityeLife","note":["Gesehen am 28.06.17"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"eLife","title":"eLife"}]}],"person":[{"given":"Jacopo","family":"Di Russo","role":"aut","roleDisplay":"VerfasserIn","display":"Di Russo, Jacopo"},{"family":"Young","given":"Jennifer","roleDisplay":"VerfasserIn","display":"Young, Jennifer","role":"aut"},{"family":"Wegner","given":"Julian W. R.","roleDisplay":"VerfasserIn","display":"Wegner, Julian W. R.","role":"aut"},{"family":"Steins","given":"Timmy","roleDisplay":"VerfasserIn","display":"Steins, Timmy","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Kessler, Horst","role":"aut","family":"Kessler","given":"Horst"},{"family":"Spatz","given":"Joachim P.","display":"Spatz, Joachim P.","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title":"Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity","title_sort":"Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity"}],"note":["Published: 23 September 2021","Gesehen am 09.03.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"1795146257","titleAlt":[{"title":"Integrin αlpha 5 beta 1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity"}]} | ||
| SRT | |a DIRUSSOJACINTEGRIN512320 | ||