Fgf-18 is required for osteogenesis but not angiogenesis during long bone repair
Bone regeneration is a complex event that requires the interaction of numerous growth factors. Fibroblast growth factor (Fgf)-ligands have been previously described for their importance in osteogenesis during development. In the current study, we investigated the role of Fgf-18 during bone regenerat...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 May 2011
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| In: |
Tissue engineering
Year: 2011, Jahrgang: 17, Heft: 15/16, Pages: 2061-2069 |
| ISSN: | 1937-335X |
| DOI: | 10.1089/ten.tea.2010.0719 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1089/ten.tea.2010.0719 Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/ten.tea.2010.0719 
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| Verfasserangaben: | Björn Behr, Michael Sorkin, Alina Manu, Marcus Lehnhardt, Michael T. Longaker, and Natalina Quarto |
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| 520 | |a Bone regeneration is a complex event that requires the interaction of numerous growth factors. Fibroblast growth factor (Fgf)-ligands have been previously described for their importance in osteogenesis during development. In the current study, we investigated the role of Fgf-18 during bone regeneration. By utilizing a unicortical tibial defect model, we revealed that mice haploinsufficient for Fgf-18 have a markedly reduced healing capacity as compared with wild-type mice. Reduced levels of Runx2 and Osteocalcin but not Vegfa accompanied the impaired bone regeneration. Interestingly, our data indicated that upon injury angiogenesis was not impaired in Fgf-18+/− mice. Moreover, other Fgf-ligands and Bmp-2 could not compensate for the loss of Fgf-18. Finally, application of FGF-18 protein was able to rescue the impaired healing in Fgf-18+/− mice. Thus, we identified Fgf-18 as an important mediator of bone regeneration, which is required during later stages of bone regeneration. This study provides hints on how to engineering efficiently programmed bony tissue for long bone repair. | ||
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