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MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated protein kinase (MAPK) pathway in HCC. Here, we systematically invest...

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Main Authors: Lin, Shibo (Author) , Hoffmann, Katrin (Author) , Xiao, Zhi (Author) , Jin, Nan (Author) , Galli, Uwe (Author) , Mohr, Elvira (Author) , Büchler, Markus W. (Author) , Schemmer, Peter (Author)
Format: Article (Journal)
Language:English
Published: 15 January 2013
In: Cancer cell international
Year: 2013, Volume: 13, Issue: 1, Pages: 1-10
ISSN:1475-2867
DOI:10.1186/1475-2867-13-3
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1475-2867-13-3
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Author Notes:Shibo Lin, Katrin Hoffmann, Zhi Xiao, Nan Jin, Uwe Galli, Elvira Mohr, Markus W. Büchler and Peter Schemmer
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Summary:Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated protein kinase (MAPK) pathway in HCC. Here, we systematically investigated the inhibition of MAPK pathway and its role in regulating HCC cell growth as well as ABC proteins MRP1 and MRP3 expression.
Item Description:Gesehen am 16.03.2022
Physical Description:Online Resource
ISSN:1475-2867
DOI:10.1186/1475-2867-13-3

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