MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma
Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated protein kinase (MAPK) pathway in HCC. Here, we systematically invest...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 January 2013
|
| In: |
Cancer cell international
Year: 2013, Jahrgang: 13, Heft: 1, Pages: 1-10 |
| ISSN: | 1475-2867 |
| DOI: | 10.1186/1475-2867-13-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1475-2867-13-3
|
| Verfasserangaben: | Shibo Lin, Katrin Hoffmann, Zhi Xiao, Nan Jin, Uwe Galli, Elvira Mohr, Markus W. Büchler and Peter Schemmer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1795729511 | ||
| 003 | DE-627 | ||
| 005 | 20230426163651.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220316s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/1475-2867-13-3 |2 doi | |
| 035 | |a (DE-627)1795729511 | ||
| 035 | |a (DE-599)KXP1795729511 | ||
| 035 | |a (OCoLC)1341446061 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lin, Shibo |d 1984- |e VerfasserIn |0 (DE-588)1035439018 |0 (DE-627)747813922 |0 (DE-576)383026229 |4 aut | |
| 245 | 1 | 0 | |a MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma |c Shibo Lin, Katrin Hoffmann, Zhi Xiao, Nan Jin, Uwe Galli, Elvira Mohr, Markus W. Büchler and Peter Schemmer |
| 264 | 1 | |c 15 January 2013 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.03.2022 | ||
| 520 | |a Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activation of mitogen activated protein kinase (MAPK) pathway in HCC. Here, we systematically investigated the inhibition of MAPK pathway and its role in regulating HCC cell growth as well as ABC proteins MRP1 and MRP3 expression. | ||
| 650 | 4 | |a Hepatocellular carcinoma | |
| 650 | 4 | |a MEK | |
| 650 | 4 | |a MRP1 | |
| 650 | 4 | |a MRP3 | |
| 650 | 4 | |a Multidrug resistance | |
| 700 | 1 | |a Hoffmann, Katrin |d 1980- |e VerfasserIn |0 (DE-588)131774417 |0 (DE-627)513946950 |0 (DE-576)252913078 |4 aut | |
| 700 | 1 | |a Xiao, Zhi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jin, Nan |d 1984- |e VerfasserIn |0 (DE-588)104518232X |0 (DE-627)773883592 |0 (DE-576)398830843 |4 aut | |
| 700 | 1 | |a Galli, Uwe |d 1967- |e VerfasserIn |0 (DE-588)12945219X |0 (DE-627)397660707 |0 (DE-576)188350233 |4 aut | |
| 700 | 1 | |a Mohr, Elvira |e VerfasserIn |4 aut | |
| 700 | 1 | |a Büchler, Markus W. |d 1955- |e VerfasserIn |0 (DE-588)120893339 |0 (DE-627)080952526 |0 (DE-576)292434146 |4 aut | |
| 700 | 1 | |a Schemmer, Peter |d 1967- |e VerfasserIn |0 (DE-588)1022604244 |0 (DE-627)717006794 |0 (DE-576)365668230 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer cell international |d London : BioMed Central, 2001 |g 13(2013), 1, 3, Seite 1-10 |h Online-Ressource |w (DE-627)355989204 |w (DE-600)2091573-1 |w (DE-576)107015315 |x 1475-2867 |7 nnas |a MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma |
| 773 | 1 | 8 | |g volume:13 |g year:2013 |g number:1 |g supplement:3 |g pages:1-10 |g extent:10 |a MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma |
| 856 | 4 | 0 | |u https://doi.org/10.1186/1475-2867-13-3 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220316 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1022604244 |a Schemmer, Peter |m 1022604244:Schemmer, Peter |d 910000 |d 910200 |d 50000 |e 910000PS1022604244 |e 910200PS1022604244 |e 50000PS1022604244 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 8 |y j | ||
| 998 | |g 120893339 |a Büchler, Markus W. |m 120893339:Büchler, Markus W. |d 910000 |d 910200 |e 910000PB120893339 |e 910200PB120893339 |k 0/910000/ |k 1/910000/910200/ |p 7 | ||
| 998 | |g 12945219X |a Galli, Uwe |m 12945219X:Galli, Uwe |d 910000 |d 910200 |e 910000PG12945219X |e 910200PG12945219X |k 0/910000/ |k 1/910000/910200/ |p 5 | ||
| 998 | |g 104518232X |a Jin, Nan |m 104518232X:Jin, Nan |d 50000 |e 50000PJ104518232X |k 0/50000/ |p 4 | ||
| 998 | |g 131774417 |a Hoffmann, Katrin |m 131774417:Hoffmann, Katrin |d 910000 |d 910200 |d 50000 |e 910000PH131774417 |e 910200PH131774417 |e 50000PH131774417 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 2 | ||
| 998 | |g 1035439018 |a Lin, Shibo |m 1035439018:Lin, Shibo |d 50000 |e 50000PL1035439018 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1795729511 |e 4090946018 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Lin, Shibo","family":"Lin","role":"aut","given":"Shibo"},{"given":"Katrin","role":"aut","display":"Hoffmann, Katrin","family":"Hoffmann"},{"given":"Zhi","family":"Xiao","display":"Xiao, Zhi","role":"aut"},{"given":"Nan","role":"aut","family":"Jin","display":"Jin, Nan"},{"family":"Galli","display":"Galli, Uwe","role":"aut","given":"Uwe"},{"given":"Elvira","role":"aut","family":"Mohr","display":"Mohr, Elvira"},{"role":"aut","family":"Büchler","display":"Büchler, Markus W.","given":"Markus W."},{"given":"Peter","role":"aut","family":"Schemmer","display":"Schemmer, Peter"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"pubHistory":["1.2001 -"],"part":{"extent":"10","year":"2013","issue":"1","text":"13(2013), 1, 3, Seite 1-10","pages":"1-10","volume":"13"},"disp":"MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinomaCancer cell international","recId":"355989204","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 27.05.2020"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Cancer cell international","title_sort":"Cancer cell international"}],"id":{"issn":["1475-2867"],"zdb":["2091573-1"],"eki":["355989204"]},"origin":[{"dateIssuedKey":"2001","dateIssuedDisp":"2001-","publisherPlace":"London","publisher":"BioMed Central"}]}],"origin":[{"dateIssuedDisp":"15 January 2013","dateIssuedKey":"2013"}],"recId":"1795729511","id":{"eki":["1795729511"],"doi":["10.1186/1475-2867-13-3"]},"physDesc":[{"extent":"10 S."}],"title":[{"title_sort":"MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma","title":"MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma"}],"language":["eng"],"note":["Gesehen am 16.03.2022"],"name":{"displayForm":["Shibo Lin, Katrin Hoffmann, Zhi Xiao, Nan Jin, Uwe Galli, Elvira Mohr, Markus W. Büchler and Peter Schemmer"]}} | ||
| SRT | |a LINSHIBOHOMEKINHIBIT1520 | ||