Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure
Heart failure (HF) is a multifactorial syndrome that remains a leading cause of worldwide morbidity. Despite its high prevalence, only half of patients with HF respond to guideline-directed medical management, prompting therapeutic efforts to confront the molecular underpinnings of its heterogeneity...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 26, 2021
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| In: |
American journal of physiology. Heart and circulatory physiology
Year: 2021, Jahrgang: 320, Heft: 5, Pages: H2066-H2079 |
| ISSN: | 1522-1539 |
| DOI: | 10.1152/ajpheart.00036.2021 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajpheart.00036.2021 Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajpheart.00036.2021 
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| Verfasserangaben: | Mark E. Pepin, Chae-Myeong Ha, Luke A. Potter, Sayan Bakshi, Joseph P. Barchue, Ayman Haj Asaad, Steven M. Pogwizd, Salpy V. Pamboukian, Bertha A. Hidalgo, Selwyn M. Vickers, Adam R. Wende |
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| 520 | |a Heart failure (HF) is a multifactorial syndrome that remains a leading cause of worldwide morbidity. Despite its high prevalence, only half of patients with HF respond to guideline-directed medical management, prompting therapeutic efforts to confront the molecular underpinnings of its heterogeneity. In the current study, we examined epigenetics as a yet unexplored source of heterogeneity among patients with end-stage HF. | ||
| 650 | 4 | |a DNA methylation | |
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| 650 | 4 | |a gene-environment interactions | |
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| 650 | 4 | |a structural racism | |
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| 700 | 1 | |a Bakshi, Sayan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Barchue, Joseph P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haj Asaad, Ayman |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pogwizd, Steven M. |e VerfasserIn |4 aut | |
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