Structured illumination ophthalmoscope: super-resolution microscopy on the living human eye
In this paper, we present the prototype of an ophthalmoscope that uses structured illumination microscopy (SIM) to enable super-resolved imaging of the human retina, and give first insights into clinical application possibilities. The SIM technique was applied to build a prototype that uses the lens...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 February 2022
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| In: |
Philosophical transactions of the Royal Society. A, Mathematical, physical and engineering sciences
Year: 2022, Volume: 380, Issue: 2220, Pages: 1-11 |
| ISSN: | 1471-2962 |
| DOI: | 10.1098/rsta.2021.0151 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1098/rsta.2021.0151 Verlag, lizenzpflichtig, Volltext: https://royalsocietypublishing.org/doi/10.1098/rsta.2021.0151 
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| Author Notes: | Florian Schock, Gerrit Best, Nil Celik, Rainer Heintzmann, Stefan Dithmar and Christoph Cremer |
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| 520 | |a In this paper, we present the prototype of an ophthalmoscope that uses structured illumination microscopy (SIM) to enable super-resolved imaging of the human retina, and give first insights into clinical application possibilities. The SIM technique was applied to build a prototype that uses the lens of the human eye as an objective to ‘super-resolve’ the retina of a living human. In our multidisciplinary collaboration, we have adapted this well-established technique in ophthalmology and successfully imaged a human retina using significantly lower light intensity than a state-of-the-art ophthalmoscope. Here, we focus on the technical implementation and highlight future perspectives of this method. A more application-oriented note for physicians on the diagnostic and disease-preventive value of this method, as well as the medical results of the clinical study carried out, will be published in a report addressed to an appropriate specialist audience. - - This article is part of the Theo Murphy meeting issue ‘Super-resolution structured illumination microscopy (part 2)' | ||
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