A novel bedside rule-in test for tuberculous meningitis in human immunodeficiency virus-infected adults
(See the Major Article by Quinn et al on pages e3428-34.)Tuberculous meningitis (TBM) likely affects >100 000 people per year [1]. While this represents approximately 1% of all tuberculosis (TB) cases, TBM is disproportionately important because it kills or severely disables half of those affecte...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
6 January 2021
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| In: |
Clinical infectious diseases
Year: 2021, Jahrgang: 73, Heft: 9, Pages: e3435-e3437 |
| ISSN: | 1537-6591 |
| DOI: | 10.1093/cid/ciaa1915 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/cid/ciaa1915
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| Verfasserangaben: | Tobias Broger and Mark P. Nicol |
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| 520 | |a (See the Major Article by Quinn et al on pages e3428-34.)Tuberculous meningitis (TBM) likely affects >100 000 people per year [1]. While this represents approximately 1% of all tuberculosis (TB) cases, TBM is disproportionately important because it kills or severely disables half of those affected [2]. Major risk factors for TBM are young age [3] and human immunodeficiency virus (HIV) infection.Diagnosis of TBM is a challenge because clinical features are nonspecific, laboratory tests are insensitive, and mycobacterial culture is too slow to have meaningful clinical impact. Treatment delay is the strongest risk factor for death [2]; sensitive diagnostics with short turnaround times are urgently needed. Rapid nucleic acid amplification tests, such as Xpert MTB/RIF Ultra (Ultra), have shown good sensitivity (77%) against culture-confirmed TBM [4], but require large cerebrospinal fluid (CSF) volumes [5] and are not yet widely available, particularly close to the point of care in many high-burden countries [6]. | ||
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