Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium
The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic recruitment and expansion of multiple cell types that interact in multifaceted ways within a localized area. Rheumatoid arthritis synovium has primarily been studied either by immunostaining or by molecular profil...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 February 2022
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| In: |
Communications biology
Year: 2022, Jahrgang: 5, Pages: 1-11 |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-022-03050-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s42003-022-03050-3 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s42003-022-03050-3 
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| Verfasserangaben: | Sanja Vickovic, Denis Schapiro, Konstantin Carlberg, Britta Lötstedt, Ludvig Larsson, Franziska Hildebrandt, Marina Korotkova, Aase H. Hensvold, Anca I. Catrina, Peter K. Sorger, Vivianne Malmström, Aviv Regev & Patrik L. Ståhl |
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| 245 | 1 | 0 | |a Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium |c Sanja Vickovic, Denis Schapiro, Konstantin Carlberg, Britta Lötstedt, Ludvig Larsson, Franziska Hildebrandt, Marina Korotkova, Aase H. Hensvold, Anca I. Catrina, Peter K. Sorger, Vivianne Malmström, Aviv Regev & Patrik L. Ståhl |
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| 520 | |a The inflamed rheumatic joint is a highly heterogeneous and complex tissue with dynamic recruitment and expansion of multiple cell types that interact in multifaceted ways within a localized area. Rheumatoid arthritis synovium has primarily been studied either by immunostaining or by molecular profiling after tissue homogenization. Here, we use Spatial Transcriptomics, where tissue-resident RNA is spatially labeled in situ with barcodes in a transcriptome-wide fashion, to study local tissue interactions at the site of chronic synovial inflammation. We report comprehensive spatial RNA-Seq data coupled to cell type-specific localization patterns at and around organized structures of infiltrating leukocyte cells in the synovium. Combining morphological features and high-throughput spatially resolved transcriptomics may be able to provide higher statistical power and more insights into monitoring disease severity and treatment-specific responses in seropositive and seronegative rheumatoid arthritis. | ||
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| 650 | 4 | |a Transcriptomics | |
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| 700 | 1 | |a Sorger, Peter K. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Ståhl, Patrik L. |e VerfasserIn |4 aut | |
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