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The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides

This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis...

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Hauptverfasser: Pham, Truc Lam (VerfasserIn) , Zilke, Jennifer (VerfasserIn) , Müller, Christine Charlotte (VerfasserIn) , Thomas, Franziska (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 18 Feb 2022
In: RSC chemical biology
Year: 2022, Pages: 1-5
ISSN:2633-0679
DOI:10.1039/D1CB00252J
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1039/D1CB00252J
Verlag, kostenfrei, Volltext: https://pubs.rsc.org/en/content/articlelanding/2022/cb/d1cb00252j
Volltext
Verfasserangaben:Truc Lam Pham, Jennifer Zilke, Christine Charlotte Müller and Franziska Thomas
Beschreibung
Zusammenfassung:This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis of CSY-protected peptides, and CSY cleavage in partially folded or aggregation-prone peptides.
Beschreibung:Gesehen am 24.03.2022
Beschreibung:Online Resource
ISSN:2633-0679
DOI:10.1039/D1CB00252J

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