The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides
This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 Feb 2022
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| In: |
RSC chemical biology
Year: 2022, Pages: 1-5 |
| ISSN: | 2633-0679 |
| DOI: | 10.1039/D1CB00252J |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1039/D1CB00252J Verlag, kostenfrei, Volltext: https://pubs.rsc.org/en/content/articlelanding/2022/cb/d1cb00252j 
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| Verfasserangaben: | Truc Lam Pham, Jennifer Zilke, Christine Charlotte Müller and Franziska Thomas |
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| 520 | |a This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis of CSY-protected peptides, and CSY cleavage in partially folded or aggregation-prone peptides. | ||
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