Cover Image

Role and Value of Luminex®-Detected HLA Antibodies before and after Kidney Transplantation

The complement-dependent lymphocytotoxicity (CDC) method has been the classical technique to detect human leukocyte antigen (HLA) antibodies in sera of patients who are listed for kidney transplantation. Because of the drawbacks of CDC, such as low sensitivity and low resolution in characterizing an...

Full description

Saved in:
Bibliographic Details
Main Authors: Süsal, Caner (Author) , Opelz, Gerhard (Author) , Morath, Christian (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Transfusion medicine and hemotherapy
Year: 2013, Volume: 40, Issue: 3, Pages: 190-195
ISSN:1660-3818
DOI:10.1159/000351314
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000351314
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/351314
Get full text
Author Notes:Caner Süsal, Gerhard Opelz, Christian Morath

MARC

LEADER 00000caa a2200000 c 4500
001 1796584940
003 DE-627
005 20230428010629.0
007 cr uuu---uuuuu
008 220324s2013 xx |||||o 00| ||eng c
024 7 |a 10.1159/000351314  |2 doi 
035 |a (DE-627)1796584940 
035 |a (DE-599)KXP1796584940 
035 |a (OCoLC)1341457966 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Süsal, Caner  |e VerfasserIn  |0 (DE-588)102648037X  |0 (DE-627)726772763  |0 (DE-576)37182673X  |4 aut 
245 1 0 |a Role and Value of Luminex®-Detected HLA Antibodies before and after Kidney Transplantation  |c Caner Süsal, Gerhard Opelz, Christian Morath 
264 1 |c 2013 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 24.03.2022 
520 |a The complement-dependent lymphocytotoxicity (CDC) method has been the classical technique to detect human leukocyte antigen (HLA) antibodies in sera of patients who are listed for kidney transplantation. Because of the drawbacks of CDC, such as low sensitivity and low resolution in characterizing antibody specificities, the more specific ELISA technology was introduced in the 1990s which utilizes solubilized HLA molecules instead of lymphocytes. During the last 10 years, the introduction of the Luminex-based single antigen bead (L-SAB) technology, which uses recombinant single HLA molecules, allows detection and characterization of HLA antibodies at greater sensitivity than CDC and ELISA. A drawback associated with this technique is that the interpretation of results is demanding and requires comprehensive experience in HLA antibody diagnostics. Herein we discuss the current role and value of L-SAB technology in the clinical management of sensitized kidney transplant recipients. 
700 1 |a Opelz, Gerhard  |d 1944-  |e VerfasserIn  |0 (DE-588)1026480345  |0 (DE-627)726772453  |0 (DE-576)371826527  |4 aut 
700 1 |a Morath, Christian  |d 1973-  |e VerfasserIn  |0 (DE-588)124036155  |0 (DE-627)085595837  |0 (DE-576)293989923  |4 aut 
773 0 8 |i Enthalten in  |t Transfusion medicine and hemotherapy  |d Basel : Karger, 2003  |g 40(2013), 3, Seite 190-195  |h Online-Ressource  |w (DE-627)360670695  |w (DE-600)2100533-3  |w (DE-576)11277542X  |x 1660-3818  |7 nnas  |a Role and Value of Luminex®-Detected HLA Antibodies before and after Kidney Transplantation 
773 1 8 |g volume:40  |g year:2013  |g number:3  |g pages:190-195  |g extent:6  |a Role and Value of Luminex®-Detected HLA Antibodies before and after Kidney Transplantation 
856 4 0 |u https://doi.org/10.1159/000351314  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.karger.com/Article/FullText/351314  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20220324 
993 |a Article 
994 |a 2013 
998 |g 124036155  |a Morath, Christian  |m 124036155:Morath, Christian  |d 50000  |e 50000PM124036155  |k 0/50000/  |p 3  |y j 
998 |g 1026480345  |a Opelz, Gerhard  |m 1026480345:Opelz, Gerhard  |d 910000  |d 911600  |e 910000PO1026480345  |e 911600PO1026480345  |k 0/910000/  |k 1/910000/911600/  |p 2 
998 |g 102648037X  |a Süsal, Caner  |m 102648037X:Süsal, Caner  |d 910000  |d 911600  |d 50000  |e 910000PS102648037X  |e 911600PS102648037X  |e 50000PS102648037X  |k 0/910000/  |k 1/910000/911600/  |k 0/50000/  |p 1  |x j 
999 |a KXP-PPN1796584940  |e 4099314553 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"recId":"1796584940","note":["Gesehen am 24.03.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Role and Value of Luminex®-Detected HLA Antibodies before and after Kidney Transplantation","title":"Role and Value of Luminex®-Detected HLA Antibodies before and after Kidney Transplantation"}],"person":[{"family":"Süsal","given":"Caner","display":"Süsal, Caner","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Opelz, Gerhard","role":"aut","family":"Opelz","given":"Gerhard"},{"role":"aut","display":"Morath, Christian","roleDisplay":"VerfasserIn","given":"Christian","family":"Morath"}],"relHost":[{"origin":[{"publisherPlace":"Basel","dateIssuedDisp":"2003-","publisher":"Karger","dateIssuedKey":"2003"}],"id":{"issn":["1660-3818"],"eki":["360670695"],"zdb":["2100533-3"]},"name":{"displayForm":["official organ of German Society for Transfusion Medicine and Immunohematology"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Transfusion medicine and hemotherapy","subtitle":"interdisciplinary journal for transfusion medicine, hemotherapy, immunohematology, and clinical hemostatis","title_sort":"Transfusion medicine and hemotherapy"}],"pubHistory":["30.2003 -"],"titleAlt":[{"title":"offizielles Organ der Deutschen Gesellschaft für Transfusionsmedizin und Immunhämatologie ; interdisziplinäre Zeitschrift für Infusions- und Hämotherapie, Immunhämatologie und klinische Hämostaseologie"}],"part":{"extent":"6","volume":"40","text":"40(2013), 3, Seite 190-195","issue":"3","pages":"190-195","year":"2013"},"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Role and Value of Luminex®-Detected HLA Antibodies before and after Kidney TransplantationTransfusion medicine and hemotherapy","note":["Gesehen am 04.05.2023","Fortsetzung der Druck-Ausgabe","Ungezählte Beil.: Supplement"],"language":["eng","ger"],"recId":"360670695"}],"physDesc":[{"extent":"6 S."}],"id":{"eki":["1796584940"],"doi":["10.1159/000351314"]},"origin":[{"dateIssuedDisp":"2013","dateIssuedKey":"2013"}],"name":{"displayForm":["Caner Süsal, Gerhard Opelz, Christian Morath"]}} 
SRT |a SUESALCANEROLEANDVAL2013 

Similar Items