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Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy

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Vascular endothelial growth factor (VEGF) plays a fundamental role in mediating tumor angiogenesis and tumor growth. Here we investigate the direct effect of a novel small molecule inhibitor of the Flk-1-mediated signal transduction pathway of VEGF, SU5416, on tumor angiogenesis and microhemodynamic...

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Main Authors: Vajkoczy, Peter (Author) , Menger, Michael D. (Author) , Vollmar, Brigitte (Author) , Schilling, Lothar (Author) , Schmiedek, Peter (Author) , Hirth, K. Peter (Author) , Ullrich, Axel (Author) , Fong, T. Annie T. (Author)
Format: Article (Journal)
Language:English
Published: 1999
In: Neoplasia
Year: 1999, Volume: 1, Issue: 1, Pages: 31-41
ISSN:1476-5586
DOI:10.1038/sj.neo.7900006
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.neo.7900006
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1476558699800335
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Author Notes:Peter Vajkoczy, Michael D. Menger, Brigitte Vollmar, Lothar Schilling, Peter Schmiedek, K. Peter Hirth, Axel Ullrich and T. Annie T. Fong
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Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy by Vajkoczy, Peter (Author) , Menger, Michael D. (Author) , Vollmar, Brigitte (Author) , Schilling, Lothar (Author) , Schmiedek, Peter (Author) , Hirth, K. Peter (Author) , Ullrich, Axel (Author) , Fong, T. Annie T. (Author) ,


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