Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity
IL-6 and its receptor(s) are found in the CNS in health and disease. Cellular sources are glial cells and neurons. Glial production of IL-6 has intensively been studied, but comparatively little is known about the induction of IL-6 in neurons. Emerging evidence suggests that IL-6 possesses neurotrop...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 1, 2002
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| In: |
The neuroscientist
Year: 2002, Volume: 8, Issue: 3, Pages: 268-275 |
| ISSN: | 1089-4098 |
| DOI: | 10.1177/1073858402008003012 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/1073858402008003012
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| Author Notes: | Eric Jüttler, Victoria Tarabin, and Markus Schwaninger |
| Summary: | IL-6 and its receptor(s) are found in the CNS in health and disease. Cellular sources are glial cells and neurons. Glial production of IL-6 has intensively been studied, but comparatively little is known about the induction of IL-6 in neurons. Emerging evidence suggests that IL-6 possesses neurotrophic properties. Recent data show that neuronal IL-6 expression is induced by excitatory amino acids or membrane depolarization. This implicates that IL-6 is produced not only under pathological conditions but may play a critical role as a physiological neuromodulator that is induced by neuronal activity and regulates brain functions. In the following article, the authors review the current data on IL-6 expression in neurons, with special reference to the induction of IL-6 by neuronal activity. They discuss its direct and indirect effects as a neuromodulator and speculate about the possible function of IL-6 as a physiological regulatory molecule and as a neuroprotective agent in brain pathology. |
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| Item Description: | Gesehen am 24.03.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1089-4098 |
| DOI: | 10.1177/1073858402008003012 |