Lipopolysaccharide/endotoxin induces IL-18 via CD14 in human peripheral blood mononuclear cells in vitro
IL-18 shares activities with IL-12 in generating T-helper 1 cells and cytokine response. It mediates LPS/endotoxin lethality by IL-12 independent interferon-γ synthesis and it induces bacteria-related organ failure. As peripheral blood mononuclear cells (PBMC) are potent producers of IL-18, we studi...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
2000
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| In: |
Cytokine
Year: 2000, Jahrgang: 12, Heft: 12, Pages: 1788-1792 |
| ISSN: | 1096-0023 |
| DOI: | 10.1006/cyto.2000.0783 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1006/cyto.2000.0783 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S104346660090783X 
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| Verfasserangaben: | Tobias Manigold, Ulrich Böcker, Petra Traber, Tuan Dong-Si, Masashi Kurimoto, Christoph Hanck, Manfred V. Singer, Siegbert Rossol |
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| 245 | 1 | 0 | |a Lipopolysaccharide/endotoxin induces IL-18 via CD14 in human peripheral blood mononuclear cells in vitro |c Tobias Manigold, Ulrich Böcker, Petra Traber, Tuan Dong-Si, Masashi Kurimoto, Christoph Hanck, Manfred V. Singer, Siegbert Rossol |
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| 520 | |a IL-18 shares activities with IL-12 in generating T-helper 1 cells and cytokine response. It mediates LPS/endotoxin lethality by IL-12 independent interferon-γ synthesis and it induces bacteria-related organ failure. As peripheral blood mononuclear cells (PBMC) are potent producers of IL-18, we studied the regulation of IL-18 upon exposure to LPS and Staphylococcus aureus (SAC) in vitro. Freshly isolated PBMC constitutively expressed IL-18 mRNA. After unstimulated preincubation for 48h, however, IL-18 transcripts were nearly not detectable by RT-PCR, but inducible by LPS or SAC (P<0.01). Both LPS and SAC were potent stimuli of IL-18 protein secretion (P<0.01). LPS-mediated IL-18 gene expression and secretion was CD14-dependent and significantly inhibited by co-incubation of PBMC with neutralizing CD14 antibody (P<0.01). We conclude that LPS-driven IL-18 is dependent on the expression of costimulatory factors and that IL-18 inhibition might attenuate IL-18-related toxic effects. | ||
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