Up-regulation of β-catenin in external auditory canal cholesteatoma
The external auditory canal cholesteatoma (EACC) is a rare disease with hyperproliferation and destructive growth in the adjacent structures. Down-regulation of β-catenin (key component of the zonula adherens) is a pivotal factor for loose tissue integrity and invasiveness. Transforming growth facto...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 1, 2005
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| In: |
International journal of molecular medicine
Year: 2005, Jahrgang: 15, Heft: 5, Pages: 801-804 |
| ISSN: | 1791-244X |
| DOI: | 10.3892/ijmm.15.5.801 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3892/ijmm.15.5.801 Verlag, lizenzpflichtig, Volltext: https://www.spandidos-publications.com/10.3892/ijmm.15.5.801 
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| Verfasserangaben: | Ramin Naim, Ray C. Chang, Clemens Anders, Haneen Sadick, Frank Riedel, Christiane Bayerl, Gregor Bran, Karl Hormann |
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| 520 | |a The external auditory canal cholesteatoma (EACC) is a rare disease with hyperproliferation and destructive growth in the adjacent structures. Down-regulation of β-catenin (key component of the zonula adherens) is a pivotal factor for loose tissue integrity and invasiveness. Transforming growth factor β1 (TGF-β1) was reported to decrease β-catenin in mammary epithelium. We investigated the abrogation of TGF-β1 and β-catenin expression in EACC culture cells. Cultured EACC-specimens were incubated with 6 µmol TGF-β1 antisense. After 48 h, expression of β-catenin was determined by means of immunohistochemistry. The cells showed an increased mural reactivity to β-catenin, and intracellular reactivity was unchanged. The untreated cells showed a loss of β-catenin expression at the membranes. The predominant membranous location after treatment with TGF-β1 antisense suggests increased tendency of the cells for tissue formation and strong cell-cell adhesion rather than migratory and invasive character, and thus TGF-β1 antisense application is a useful therapeutical strategy. | ||
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