Estriol induced squamous metaplasia on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia
Background - The aim of this study was to evaluate by light and electron microscopy the effect of topical estriol on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia (HHT). - Methods - Twelve patients were instructed to apply twice daily 0.1% estriol as a nose ointment over a...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[September-October 2005]
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| In: |
Archives of medical research
Year: 2005, Volume: 36, Issue: 5, Pages: 468-473 |
| ISSN: | 1873-5487 |
| DOI: | 10.1016/j.arcmed.2005.03.037 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.arcmed.2005.03.037 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0188440905001360 
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| Author Notes: | Haneen Sadick, Wolfgang F. Bergler, Jasmina Oulmi-Kagermann, Ramin Naim, Maliha Sadick, Karl Hörmann, Frank Riedel |
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| 245 | 1 | 0 | |a Estriol induced squamous metaplasia on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia |c Haneen Sadick, Wolfgang F. Bergler, Jasmina Oulmi-Kagermann, Ramin Naim, Maliha Sadick, Karl Hörmann, Frank Riedel |
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| 520 | |a Background - The aim of this study was to evaluate by light and electron microscopy the effect of topical estriol on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia (HHT). - Methods - Twelve patients were instructed to apply twice daily 0.1% estriol as a nose ointment over a period of 12 months. Written consent was obtained from each patient, allowing biopsy specimens of the nasal mucosa to be taken prior to and 3, 6 and 12 months after estriol application. - Results - Metaplastic change of the nasal mucosa was observed 6 months after topical estriol application. The former ciliated columnar epithelium changed into a keratinizing squamous epithelium. The effect was reversible after discontinuation of estriol application. - Conclusions - For the first time, we could outline the effect of topical estriol on the nasal mucosa. These histomorphological findings, and the fact that estriol is a low-potency metabolite of estradiol, make estriol a valuable agent in the treatment of HHT patients. | ||
| 650 | 4 | |a Estriol | |
| 650 | 4 | |a Hereditary hemorrhagic telangiectasia (HHT) | |
| 650 | 4 | |a Light and electron microscopic study | |
| 650 | 4 | |a Squamous metaplasia | |
| 650 | 4 | |a Topical estrogens | |
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