Antioxidant multi-walled carbon nanotubes by free radical grafting of gallic acid: new materials for biomedical applications
To prove the possibility of covalently functionalizing multi-walled carbon nanotubes (CNTs) by free radical grafting of gallic acid on their surface with the subsequent synthesis of materials with improved biological properties evaluated by specific in-vitro assays.Antioxidant CNTs were synthesized...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
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| In: |
Journal of pharmacy and pharmacology
Year: 2011, Jahrgang: 63, Heft: 2, Pages: 179-188 |
| ISSN: | 2042-7158 |
| DOI: | 10.1111/j.2042-7158.2010.01211.x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/j.2042-7158.2010.01211.x Verlag, kostenfrei, Volltext: https://academic.oup.com/jpp/article/63/2/179/6135483?login=true 
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| Verfasserangaben: | Giuseppe Cirillo, Silke Hampel, Rüdiger Klingeler, Francesco Puoci, Francesca Iemma, Manuela Curcio, Ortensia Ilaria Parisi, Umile Gianfranco Spizzirri, Nevio Picci, Albrecht Leonhardt, Manfred Ritschel and Bernd Büchner |
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| 245 | 1 | 0 | |a Antioxidant multi-walled carbon nanotubes by free radical grafting of gallic acid |b new materials for biomedical applications |c Giuseppe Cirillo, Silke Hampel, Rüdiger Klingeler, Francesco Puoci, Francesca Iemma, Manuela Curcio, Ortensia Ilaria Parisi, Umile Gianfranco Spizzirri, Nevio Picci, Albrecht Leonhardt, Manfred Ritschel and Bernd Büchner |
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| 520 | |a To prove the possibility of covalently functionalizing multi-walled carbon nanotubes (CNTs) by free radical grafting of gallic acid on their surface with the subsequent synthesis of materials with improved biological properties evaluated by specific in-vitro assays.Antioxidant CNTs were synthesized by radical grafting of gallic acid onto pristine CNTs. The synthesis of carbon nanotubes was carried out in a fixed-bed reactor and, after the removal of the amorphous carbon, the grafting process was performed. The obtained materials were characterized by fluorescence and Fourier transform infrared spectroscopy (FT-IR) analyses. After assessment of the biocompatibility and determination of the disposable phenolic group content, the antioxidant properties were evaluated in terms of total antioxidant activity and scavenger ability against 2,2′-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl and peroxyl radicals. Finally the inhibition activity on acetylcholinesterase was evaluated.The covalent fuctionalization of CNTs with gallic acid was confirmed and the amount of gallic acid bound per g of CNTs was found to be 2.1 ± 0.2 mg. Good antioxidant and scavenging properties were recorded in the functionalized CNTs, which were found to be able to inhibit the acetylcholinesterase with potential improved activity for biomedical and pharmaceutical applications.For the first time, a free radical grafting procedure was proposed as a synthetic approach for the covalent functionalization of CNTs with an antioxidant polyphenol. | ||
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| 700 | 1 | |a Puoci, Francesco |e VerfasserIn |4 aut | |
| 700 | 1 | |a Iemma, Francesca |e VerfasserIn |4 aut | |
| 700 | 1 | |a Curcio, Manuela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Parisi, Ortensia Ilaria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Spizzirri, Umile Gianfranco |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Leonhardt, Albrecht |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ritschel, Manfred |e VerfasserIn |4 aut | |
| 700 | 1 | |a Büchner, Bernd |e VerfasserIn |4 aut | |
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