Neurotransmitter metabolites in CSF: an external quality control scheme
We report an international external quality control scheme on neurotransmitter metabolites in cerebrospinal fluid (CSF). The neurotransmitter metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are analysed to diagnose inborn errors of...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 June 2002
|
| In: |
Journal of inherited metabolic disease
Year: 2002, Jahrgang: 25, Heft: 4, Pages: 287-298 |
| ISSN: | 1573-2665 |
| DOI: | 10.1023/A:1016550324235 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1023/A:1016550324235 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1023/A%3A1016550324235 
|
| Verfasserangaben: | C. Bräutigam, C. Weykamp, G.F. Hoffmann, R.A. Wevers |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1797043986 | ||
| 003 | DE-627 | ||
| 005 | 20230428010715.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220330s2002 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1023/A:1016550324235 |2 doi | |
| 035 | |a (DE-627)1797043986 | ||
| 035 | |a (DE-599)KXP1797043986 | ||
| 035 | |a (OCoLC)1341458256 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bräutigam, Christa |e VerfasserIn |0 (DE-588)123231760 |0 (DE-627)706219104 |0 (DE-576)293614695 |4 aut | |
| 245 | 1 | 0 | |a Neurotransmitter metabolites in CSF |b an external quality control scheme |c C. Bräutigam, C. Weykamp, G.F. Hoffmann, R.A. Wevers |
| 264 | 1 | |c 01 June 2002 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.03.2022 | ||
| 520 | |a We report an international external quality control scheme on neurotransmitter metabolites in cerebrospinal fluid (CSF). The neurotransmitter metabolites homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) are analysed to diagnose inborn errors of neurotransmitter metabolism. HVA is the catabolite of dopamine; 5-HIAA is the catabolite of serotonin; and MHPG is the catabolite of noradrenaline. In the first phase, 12 laboratories from six countries participated in this special quality control scheme to define the present state of the art and achieve harmonization in analytical outcome and interpretation. In the second part, recoveries, dilutions and methods for sample preparation were compared. The results of 3 of 12 laboratories were excluded because of unacceptable intralaboratory coefficients of variations (CV) for HVA and/or 5-HIAA. The inter- and intralaboratory CVs, the linearity and the recovery were acceptable for the other laboratories for both parameters.Unacceptable differences in the reference ranges between laboratories, leading to differences in interpretation of the results, became obvious. There was a significant improvement of the interlaboratory CV for HVA after standardization with a calibrator. The reproducibility of MHPG measurement appeared to be adequately established in only two laboratories and recovery was low in all five measuring this metabolite. The quality control scheme is an invaluable tool for controlling the analytical outcome and providing support to laboratories to improve their quality. | ||
| 700 | 1 | |a Weykamp, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hoffmann, Georg F. |d 1957- |e VerfasserIn |0 (DE-588)115652868 |0 (DE-627)077386116 |0 (DE-576)261230042 |4 aut | |
| 700 | 1 | |a Wevers, R. A. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of inherited metabolic disease |d Hoboken, NJ : Wiley, 1978 |g 25(2002), 4, Seite 287-298 |h Online-Ressource |w (DE-627)320457753 |w (DE-600)2006875-X |w (DE-576)105704652 |x 1573-2665 |7 nnas |a Neurotransmitter metabolites in CSF an external quality control scheme |
| 773 | 1 | 8 | |g volume:25 |g year:2002 |g number:4 |g pages:287-298 |g extent:12 |a Neurotransmitter metabolites in CSF an external quality control scheme |
| 856 | 4 | 0 | |u https://doi.org/10.1023/A:1016550324235 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1023/A%3A1016550324235 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220330 | ||
| 994 | |a 2002 | ||
| 998 | |g 115652868 |a Hoffmann, Georg F. |m 115652868:Hoffmann, Georg F. |p 3 | ||
| 998 | |g 123231760 |a Bräutigam, Christa |m 123231760:Bräutigam, Christa |d 910000 |d 910500 |e 910000PB123231760 |e 910500PB123231760 |k 0/910000/ |k 1/910000/910500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1797043986 |e 4106964031 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"extent":"12 S."}],"title":[{"title_sort":"Neurotransmitter metabolites in CSF","title":"Neurotransmitter metabolites in CSF","subtitle":"an external quality control scheme"}],"person":[{"role":"aut","given":"Christa","family":"Bräutigam","display":"Bräutigam, Christa"},{"display":"Weykamp, C.","family":"Weykamp","given":"C.","role":"aut"},{"given":"Georg F.","role":"aut","family":"Hoffmann","display":"Hoffmann, Georg F."},{"family":"Wevers","given":"R. A.","role":"aut","display":"Wevers, R. A."}],"recId":"1797043986","name":{"displayForm":["C. Bräutigam, C. Weykamp, G.F. Hoffmann, R.A. Wevers"]},"origin":[{"dateIssuedDisp":"01 June 2002","dateIssuedKey":"2002"}],"id":{"doi":["10.1023/A:1016550324235"],"eki":["1797043986"]},"note":["Gesehen am 30.03.2022"],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.1978 -"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"JIMD"}],"note":["Gesehen am 11.03.20","Ungezählte Beil.: Suppl"],"title":[{"title_sort":"Journal of inherited metabolic disease","subtitle":"JIMD ; official journal of the Society for the Study of Inborn Errors of Metabolism","title":"Journal of inherited metabolic disease"}],"disp":"Neurotransmitter metabolites in CSF an external quality control schemeJournal of inherited metabolic disease","recId":"320457753","part":{"year":"2002","issue":"4","volume":"25","pages":"287-298","text":"25(2002), 4, Seite 287-298","extent":"12"},"id":{"doi":["10.1002/(ISSN)1573-2665"],"zdb":["2006875-X"],"issn":["1573-2665"],"eki":["320457753"]},"origin":[{"publisher":"Wiley ; Kluwer ; Springer Science + Business Media B.V","dateIssuedKey":"1978","dateIssuedDisp":"1978-","publisherPlace":"Hoboken, NJ ; Dordrecht [u.a.] ; Dordrecht [u.a.]"}]}]} | ||
| SRT | |a BRAEUTIGAMNEUROTRANS0120 | ||