Disease-free survival as a surrogate for overall survival in upper tract urothelial carcinoma

The primary endpoint in trials of perioperative systemic therapy for urothelial carcinoma is 5-year overall survival (OS). A shorter-term endpoint could significantly speed the translation of advances into practice. We hypothesized that disease-free survival (DFS) could be a surrogate endpoint for O...

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Main Authors: Fajkovic, Harun (Author) , Cha, Eugene K. (Author) , Xylinas, Evanguelos (Author) , Rink, Michael (Author) , Pycha, Armin (Author) , Seitz, Christian (Author) , Bolenz, Christian (Author) , Dunning, Allison (Author) , Novara, Giacomo (Author) , Trinh, Quoc-Dien (Author) , Karakiewicz, Pierre I. (Author) , Margulis, Vitaly (Author) , Raman, Jay D. (Author) , Walton, Thomas J. (Author) , Baba, Shiro (Author) , Carballido, Joaquin (Author) , Otto, Wolfgang (Author) , Montorsi, Francesco (Author) , Lotan, Yair (Author) , Kassouf, Wassim (Author) , Fritsche, Hans-Martin (Author) , Bensalah, Karim (Author) , Zigeuner, Richard (Author) , Scherr, Douglas S. (Author) , Sonpavde, Guru (Author) , Roupret, Morgan (Author) , Shariat, Shahrokh F. (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: World journal of urology
Year: 2013, Volume: 31, Issue: 1, Pages: 5-11
ISSN:1433-8726
DOI:10.1007/s00345-012-0939-5
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00345-012-0939-5
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Author Notes:Harun Fajkovic, Eugene K. Cha, Evanguelos Xylinas, Michael Rink, Armin Pycha, Christian Seitz, Christian Bolenz, Allison Dunning, Giacomo Novara, Quoc-Dien Trinh, Pierre I. Karakiewicz, Vitaly Margulis, Jay D. Raman, Thomas J. Walton, Shiro Baba, Joaquin Carballido, Wolfgang Otto, Francesco Montorsi, Yair Lotan, Wassim Kassouf, Hans-Martin Fritsche, Karim Bensalah, Richard Zigeuner, Douglas S. Scherr, Guru Sonpavde, Morgan Roupret, Shahrokh F. Shariat
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Summary:The primary endpoint in trials of perioperative systemic therapy for urothelial carcinoma is 5-year overall survival (OS). A shorter-term endpoint could significantly speed the translation of advances into practice. We hypothesized that disease-free survival (DFS) could be a surrogate endpoint for OS in upper tract urothelial carcinoma (UTUC) patients treated with radical nephroureterectomy (RNU).
Item Description:Gesehen am 31.03.2022
Physical Description:Online Resource
ISSN:1433-8726
DOI:10.1007/s00345-012-0939-5