The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA
The monomeric GTPase RhoA, which is a key regulator of numerous cellular processes, is activated by a variety of G protein-coupled receptors, through either G12 or G(q) family proteins. Here we report that p63RhoGEF, a recently identified RhoA-specific guanine nucleotide exchange factor, enhances th...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 January 2005
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| In: |
The journal of biological chemistry
Year: 2005, Jahrgang: 280, Heft: 12, Pages: 11134-11139 |
| ISSN: | 1083-351X |
| DOI: | 10.1074/jbc.M411322200 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1074/jbc.M411322200
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| Verfasserangaben: | Susanne Lutz, Andrea Freichel-Blomquist, Yang Yang, Ulrich Rümenapp, Karl H. Jakobs, Martina Schmidt, Thomas Wieland |
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| 245 | 1 | 4 | |a The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA |c Susanne Lutz, Andrea Freichel-Blomquist, Yang Yang, Ulrich Rümenapp, Karl H. Jakobs, Martina Schmidt, Thomas Wieland |
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| 520 | |a The monomeric GTPase RhoA, which is a key regulator of numerous cellular processes, is activated by a variety of G protein-coupled receptors, through either G12 or G(q) family proteins. Here we report that p63RhoGEF, a recently identified RhoA-specific guanine nucleotide exchange factor, enhances the Rho-dependent gene transcription induced by agonist-stimulated G(q/11)-coupled receptors (M3-cholinoceptor, histamine H1 receptor) or GTPase-deficient mutants of G alpha(q) and G alpha11. We further demonstrate that active G alpha(q) or G alpha11, but not G alpha12 or G alpha13, strongly enhances p63RhoGEF-induced RhoA activation by direct protein-protein interaction with p63RhoGEF at its C-terminal half. Moreover, the activation of p63RhoGEF by G alpha(q/11) occurs independently of and in competition to the activation of the canonical G alpha(q/11) effector phospholipase C beta. Therefore, our results elucidate a new signaling pathway by which G alpha(q/11)-coupled receptors specifically induce Rho signaling through a direct interaction of activated G alpha(q/11) subunits with p63RhoGEF. | ||
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| 650 | 4 | |a Binding Sites | |
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| 650 | 4 | |a GTP-Binding Protein alpha Subunits, G12-G13 | |
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| 650 | 4 | |a Guanine Nucleotide Exchange Factors | |
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| 650 | 4 | |a Isoenzymes | |
| 650 | 4 | |a Phospholipase C beta | |
| 650 | 4 | |a Rho Guanine Nucleotide Exchange Factors | |
| 650 | 4 | |a rhoA GTP-Binding Protein | |
| 650 | 4 | |a Signal Transduction | |
| 650 | 4 | |a Transcription, Genetic | |
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