Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of Gq/11, Gi and G12/13 proteins in signalling by α1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors
Using adenoviruses encoding RGS2, RGS4 and Lsc (regulator of G protein signalling (RGS) domain of p115 RhoGEF), we investigated the contributions of G(q/11), Gi and G(12/13) proteins to G protein-coupled receptor (GPCR)-mediated activation of the extracellular signal-regulated kinase (ERK) pathway i...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2005
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| In: |
Cellular signalling
Year: 2005, Jahrgang: 17, Heft: 5, Pages: 655-664 |
| ISSN: | 1873-3913 |
| DOI: | 10.1016/j.cellsig.2004.10.008 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cellsig.2004.10.008
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| Verfasserangaben: | Andrew K. Snabaitis, Andreas Muntendorf, Thomas Wieland, Metin Avkiran |
MARC
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| 245 | 1 | 0 | |a Regulation of the extracellular signal-regulated kinase pathway in adult myocardium |b differential roles of Gq/11, Gi and G12/13 proteins in signalling by α1-adrenergic, endothelin-1 and thrombin-sensitive protease-activated receptors |c Andrew K. Snabaitis, Andreas Muntendorf, Thomas Wieland, Metin Avkiran |
| 246 | 3 | 0 | |a G q/11, G i and G 12/13 alpha1-adrenergic |
| 264 | 1 | |c 2005 | |
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| 520 | |a Using adenoviruses encoding RGS2, RGS4 and Lsc (regulator of G protein signalling (RGS) domain of p115 RhoGEF), we investigated the contributions of G(q/11), Gi and G(12/13) proteins to G protein-coupled receptor (GPCR)-mediated activation of the extracellular signal-regulated kinase (ERK) pathway in adult rat ventricular myocytes (ARVM). Exposure to phenylephrine, endothelin-1 (ET-1) or thrombin induced significant activation of ERK1/2 and their downstream target 90 kDa ribosomal S6 kinase (p90RSK), which was abolished by overexpression of RGS4 (inhibits signalling via G(q/11) and Gi) or RGS2 (inhibits signalling via G(q/11)). Pertussis toxin (inhibits signalling via Gi) only partially attenuated the activation of ERK1/2 and p90(RSK) by phenylephrine and ET-1, but abolished such activation by thrombin. Overexpression of Lsc (inhibits signalling via G(12/13)) did not affect the responses to phenylephrine and ET-1, but suppressed the activation of ERK1/2 and p90RSK by thrombin. We conclude that full activation of the ERK pathway in ARVM by alpha1-adrenergic, ET-1 and thrombin receptors requires the activation of distinct families of heterotrimeric G proteins. | ||
| 650 | 4 | |a Adenoviridae | |
| 650 | 4 | |a Adrenergic alpha-1 Receptor Agonists | |
| 650 | 4 | |a Adrenergic alpha-Agonists | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Genetic Vectors | |
| 650 | 4 | |a GTP-Binding Protein alpha Subunits | |
| 650 | 4 | |a GTP-Binding Protein alpha Subunits, G12-G13 | |
| 650 | 4 | |a GTP-Binding Protein alpha Subunits, Gi-Go | |
| 650 | 4 | |a GTP-Binding Protein alpha Subunits, Gq-G11 | |
| 650 | 4 | |a Guanine Nucleotide Exchange Factors | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a MAP Kinase Signaling System | |
| 650 | 4 | |a Myocytes, Cardiac | |
| 650 | 4 | |a Pertussis Toxin | |
| 650 | 4 | |a Phenylephrine | |
| 650 | 4 | |a Protein Structure, Tertiary | |
| 650 | 4 | |a Rats | |
| 650 | 4 | |a Rats, Wistar | |
| 650 | 4 | |a Receptor, Endothelin A | |
| 650 | 4 | |a Receptors, Adrenergic, alpha-1 | |
| 650 | 4 | |a Receptors, G-Protein-Coupled | |
| 650 | 4 | |a Receptors, Thrombin | |
| 650 | 4 | |a RGS Proteins | |
| 650 | 4 | |a Rho Guanine Nucleotide Exchange Factors | |
| 700 | 1 | |a Muntendorf, Andreas |d 1976- |e VerfasserIn |0 (DE-588)136833349 |0 (DE-627)587802928 |0 (DE-576)30130016X |4 aut | |
| 700 | 1 | |a Wieland, Thomas |d 1960-2025 |e VerfasserIn |0 (DE-588)1033445908 |0 (DE-627)741233215 |0 (DE-576)381043339 |4 aut | |
| 700 | 1 | |a Avkiran, Metin |e VerfasserIn |4 aut | |
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