Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization
Objectives: Little is known about the extent of intratumoral genetic heterogeneity in head and neck squamous cell carcinoma (HNSCC). Material: Therefore, we examined 79 stage III and IV primary HNSCCs and matched lymph node metastases for over- and underrepresentation of specific chromosome regions...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Kapitel/Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
[2005]
|
| In: |
Current research in head and neck cancer
Year: 2005, Pages: 38-48 |
| DOI: | 10.1159/000082462 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000082462 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/82462 
|
| Verfasserangaben: | Karl Götte, Susanne C. Tremmel, Susanne Popp, Susanne Weber, Karl Hörmann, Claus R. Bartram, Anna Jauch |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1797389270 | ||
| 003 | DE-627 | ||
| 005 | 20220820155934.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220401s2005 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000082462 |2 doi | |
| 035 | |a (DE-627)1797389270 | ||
| 035 | |a (DE-599)KXP1797389270 | ||
| 035 | |a (OCoLC)1341458211 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Götte, Karl |e VerfasserIn |0 (DE-588)140224920 |0 (DE-627)616951051 |0 (DE-576)315283424 |4 aut | |
| 245 | 1 | 0 | |a Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization |c Karl Götte, Susanne C. Tremmel, Susanne Popp, Susanne Weber, Karl Hörmann, Claus R. Bartram, Anna Jauch |
| 264 | 1 | |c [2005] | |
| 300 | |b Diagramme | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.04.2022 | ||
| 520 | |a Objectives: Little is known about the extent of intratumoral genetic heterogeneity in head and neck squamous cell carcinoma (HNSCC). Material: Therefore, we examined 79 stage III and IV primary HNSCCs and matched lymph node metastases for over- and underrepresentation of specific chromosome regions by comparative genomic hybridization. Results: The overall ratio of gains and losses was higher in metastases (M) than in primary (P) tumors (4/1 vs. 2.5/1). Gains of 3q (78.1% P vs. 87.5% M) and 11q (78.1% P vs. 62.5% M), and deletions of 3p (43.8% P vs. 34.4% M) and 9p (31.3% P vs. 15.6% M) were most frequently detected. The highest rate of intratumoral discordance was observed for primary tumors and corresponding metastases (32.8%) compared to matched pairs of 2 metastases (26.5%), and of 2 anatomically distinct sides of 1 primary tumor (24.3%). Furthermore, the discordance rate was dependent on the primary tumor site (oral cavity 49.2%, oropharynx 31%, hypopharynx 30.3% and larynx 27.3%). In some tumors, the extent of genomic discordance argues against a monoclonal origin. Conclusion: We demonstrate a high individual variation of intratumoral genomic heterogeneity depending on the localization and selection of matched pairs. These findings are of specific importance in view of establishing prognostic markers. | ||
| 700 | 1 | |a Tremmel, Susanne Carina |d 1974- |e VerfasserIn |0 (DE-588)129682284 |0 (DE-627)477120067 |0 (DE-576)297784005 |4 aut | |
| 700 | 1 | |a Popp, Susanne |e VerfasserIn |0 (DE-588)1254665536 |0 (DE-627)1797390430 |4 aut | |
| 700 | 1 | |a Weber, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hörmann, Karl |d 1948- |e VerfasserIn |0 (DE-588)130123749 |0 (DE-627)49171193X |0 (DE-576)266607438 |4 aut | |
| 700 | 1 | |a Bartram, Claus R. |d 1952- |e VerfasserIn |0 (DE-588)139758518 |0 (DE-627)613089502 |0 (DE-576)312997159 |4 aut | |
| 700 | 1 | |a Jauch, Anna |d 1959- |e VerfasserIn |0 (DE-588)1025525140 |0 (DE-627)722525362 |0 (DE-576)168357496 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current research in head and neck cancer |d Basel : Karger, 2005 |g (2005), Seite 38-48 |h VI + 208 S. |w (DE-627)621662070 |w (DE-576)9621662079 |z 9783318011197 |7 nnam |a Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization |
| 773 | 1 | 8 | |g year:2005 |g pages:38-48 |g extent:11 |a Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization |
| 856 | 4 | 0 | |u https://doi.org/10.1159/000082462 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.karger.com/Article/FullText/82462 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220401 | ||
| 993 | |a BookComponentPart | ||
| 994 | |a 2005 | ||
| 998 | |g 1025525140 |a Jauch, Anna |m 1025525140:Jauch, Anna |d 910000 |d 911500 |e 910000PJ1025525140 |e 911500PJ1025525140 |k 0/910000/ |k 1/910000/911500/ |p 7 |y j | ||
| 998 | |g 139758518 |a Bartram, Claus R. |m 139758518:Bartram, Claus R. |d 910000 |d 911500 |e 910000PB139758518 |e 911500PB139758518 |k 0/910000/ |k 1/910000/911500/ |p 6 | ||
| 998 | |g 130123749 |a Hörmann, Karl |m 130123749:Hörmann, Karl |d 60000 |d 62100 |e 60000PH130123749 |e 62100PH130123749 |k 0/60000/ |k 1/60000/62100/ |p 5 | ||
| 998 | |g 1254665536 |a Popp, Susanne |m 1254665536:Popp, Susanne |d 910000 |d 911500 |e 910000PP1254665536 |e 911500PP1254665536 |k 0/910000/ |k 1/910000/911500/ |p 3 | ||
| 998 | |g 129682284 |a Tremmel, Susanne Carina |m 129682284:Tremmel, Susanne Carina |d 910000 |d 911500 |e 910000PT129682284 |e 911500PT129682284 |k 0/910000/ |k 1/910000/911500/ |p 2 | ||
| 998 | |g 140224920 |a Götte, Karl |m 140224920:Götte, Karl |d 60000 |d 62100 |e 60000PG140224920 |e 62100PG140224920 |k 0/60000/ |k 1/60000/62100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1797389270 |e 410970619X | ||
| BIB | |a Y | ||
| JSO | |a {"relHost":[{"recId":"621662070","name":{"displayForm":["vol. ed.: Henning Bier"]},"disp":"Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridizationCurrent research in head and neck cancer","part":{"extent":"11","year":"2005","text":"(2005), Seite 38-48","pages":"38-48"},"title":[{"title_sort":"Current research in head and neck cancer","title":"Current research in head and neck cancer","subtitle":"molecular pathways, novel therapeutic targets, and prognostic factors ; new insights into basic and translational research"}],"person":[{"role":"edt","given":"Henning","family":"Bier","display":"Bier, Henning"}],"physDesc":[{"extent":"VI + 208 S."}],"relMultPart":[{"disp":"Advances in oto-rhino-laryngology","note":["Gesehen am 28.06.2024"],"pubHistory":["Vol. 17-"],"recId":"61751271X","id":{"eki":["61751271X"],"zdb":["2534915-6"],"issn":["1662-2847"]},"type":{"media":"Online-Ressource","bibl":"serial"},"language":["eng"],"origin":[{"publisherPlace":"Basel","dateIssuedDisp":"1970-","publisher":"Karger","dateIssuedKey":"1970"}],"dispAlt":"Advances in oto-rhino-laryngology","title":[{"title":"Advances in oto-rhino-laryngology","subtitle":" = Fortschritte der Hals-, Nasen-, Ohrenheilkunde = Progrès en oto-rhino-laryngologie","title_sort":"Advances in oto-rhino-laryngology"}],"physDesc":[{"extent":"Online-Ressource"}],"titleTranslated":[{"translated":"Fortschritte der Hals-, Nasen-, Ohrenheilkunde"},{"translated":"Progrès en oto-rhino-laryngologie"}],"part":{"number":["62"],"number_sort":["62"]}}],"id":{"eki":["621662070"],"doi":["10.1159/isbn.978-3-318-01119-7"],"isbn":["9783318011197"]},"type":{"bibl":"edited-book","media":"Online-Ressource"},"language":["eng"],"origin":[{"dateIssuedKey":"2005","publisher":"Karger","dateIssuedDisp":"2005","publisherPlace":"Basel"}]}],"physDesc":[{"extent":"11 S.","noteIll":"Diagramme"}],"person":[{"given":"Karl","family":"Götte","display":"Götte, Karl","role":"aut"},{"given":"Susanne Carina","family":"Tremmel","display":"Tremmel, Susanne Carina","role":"aut"},{"given":"Susanne","display":"Popp, Susanne","family":"Popp","role":"aut"},{"role":"aut","given":"Susanne","family":"Weber","display":"Weber, Susanne"},{"role":"aut","given":"Karl","family":"Hörmann","display":"Hörmann, Karl"},{"family":"Bartram","display":"Bartram, Claus R.","given":"Claus R.","role":"aut"},{"role":"aut","given":"Anna","family":"Jauch","display":"Jauch, Anna"}],"title":[{"title":"Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization","title_sort":"Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization"}],"origin":[{"dateIssuedDisp":"[2005]","dateIssuedKey":"2005"}],"id":{"doi":["10.1159/000082462"],"eki":["1797389270"]},"type":{"media":"Online-Ressource","bibl":"chapter"},"language":["eng"],"note":["Gesehen am 01.04.2022"],"recId":"1797389270","name":{"displayForm":["Karl Götte, Susanne C. Tremmel, Susanne Popp, Susanne Weber, Karl Hörmann, Claus R. Bartram, Anna Jauch"]}} | ||
| SRT | |a GOETTEKARLINTRATUMOR2005 | ||