Intratumoral genomic heterogeneity in advanced head and neck cancer detected by comparative genomic hybridization
Objectives: Little is known about the extent of intratumoral genetic heterogeneity in head and neck squamous cell carcinoma (HNSCC). Material: Therefore, we examined 79 stage III and IV primary HNSCCs and matched lymph node metastases for over- and underrepresentation of specific chromosome regions...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Kapitel/Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
[2005]
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| In: |
Current research in head and neck cancer
Year: 2005, Pages: 38-48 |
| DOI: | 10.1159/000082462 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000082462 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/82462 
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| Verfasserangaben: | Karl Götte, Susanne C. Tremmel, Susanne Popp, Susanne Weber, Karl Hörmann, Claus R. Bartram, Anna Jauch |
| Zusammenfassung: | Objectives: Little is known about the extent of intratumoral genetic heterogeneity in head and neck squamous cell carcinoma (HNSCC). Material: Therefore, we examined 79 stage III and IV primary HNSCCs and matched lymph node metastases for over- and underrepresentation of specific chromosome regions by comparative genomic hybridization. Results: The overall ratio of gains and losses was higher in metastases (M) than in primary (P) tumors (4/1 vs. 2.5/1). Gains of 3q (78.1% P vs. 87.5% M) and 11q (78.1% P vs. 62.5% M), and deletions of 3p (43.8% P vs. 34.4% M) and 9p (31.3% P vs. 15.6% M) were most frequently detected. The highest rate of intratumoral discordance was observed for primary tumors and corresponding metastases (32.8%) compared to matched pairs of 2 metastases (26.5%), and of 2 anatomically distinct sides of 1 primary tumor (24.3%). Furthermore, the discordance rate was dependent on the primary tumor site (oral cavity 49.2%, oropharynx 31%, hypopharynx 30.3% and larynx 27.3%). In some tumors, the extent of genomic discordance argues against a monoclonal origin. Conclusion: We demonstrate a high individual variation of intratumoral genomic heterogeneity depending on the localization and selection of matched pairs. These findings are of specific importance in view of establishing prognostic markers. |
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| Beschreibung: | Gesehen am 01.04.2022 |
| Beschreibung: | Online Resource |
| ISBN: | 9783318011197 |
| DOI: | 10.1159/000082462 |