Detailed long-term dynamics of neutrophil-to-lymphocyte ratio under biologic treatment reveal differential effects of tumour necrosis factor-alpha and interleukin 12/23 antagonists
Psoriasis is thought to be associated with a reduced life expectancy through systemic inflammation. A comparative, retrospective analysis of neutrophil-to-lympho-cyte ratio, a biomarker of systemic inflammation and cardiovascular risk, under 196 treatments with tumour necrosis factor-α and interleuk...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
Sep 30, 2021
|
| In: |
Acta dermato-venereologica
Year: 2021, Volume: 101, Issue: 10, Pages: 1-5 |
| ISSN: | 1651-2057 |
| DOI: | 10.2340/actadv.v101.271 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2340/actadv.v101.271 Verlag, lizenzpflichtig, Volltext: https://medicaljournalssweden.se/actadv/article/view/271 
|
| Author Notes: | Jochen H.O. Hoffmann, Christian Knoop, Alexander H. Enk and Eva N. Hadaschik |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 179741156X | ||
| 003 | DE-627 | ||
| 005 | 20220820160102.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220404s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2340/actadv.v101.271 |2 doi | |
| 035 | |a (DE-627)179741156X | ||
| 035 | |a (DE-599)KXP179741156X | ||
| 035 | |a (OCoLC)1341458431 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hoffmann, Jochen |e VerfasserIn |0 (DE-588)1074973267 |0 (DE-627)832794430 |0 (DE-576)443176698 |4 aut | |
| 245 | 1 | 0 | |a Detailed long-term dynamics of neutrophil-to-lymphocyte ratio under biologic treatment reveal differential effects of tumour necrosis factor-alpha and interleukin 12/23 antagonists |c Jochen H.O. Hoffmann, Christian Knoop, Alexander H. Enk and Eva N. Hadaschik |
| 264 | 1 | |c Sep 30, 2021 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.04.2022 | ||
| 520 | |a Psoriasis is thought to be associated with a reduced life expectancy through systemic inflammation. A comparative, retrospective analysis of neutrophil-to-lympho-cyte ratio, a biomarker of systemic inflammation and cardiovascular risk, under 196 treatments with tumour necrosis factor-α and interleukin-12/23 antagonists was performed. Neutrophil-to-lympho-cyte ratio decreased significantly within 3 months of initiation of treatment and remained stable at reduced levels for at least 33 months. Dynamics were more pronounced and neutrophil-to-lympho-cyte ratio under treatment was lower in patients treated with tumour necrosis factor-α compared with interleukin-12/23 antagonists (geometric mean (95% confidence interval): 2.03 (1.9, 2.1) vs 2.63 (2.2, 3.2), respectively, p = 0.014). tumour necrosis factor-α antagonist treatment and baseline neutrophil-to-lympho-cyte ratio were independent predictors of a median low cardiovascular risk neutrophil-to-lympho-cyte ratio (< 2.15) during treatment (odds ratio (95% confidence interval): 0.53 (0.4-0.8) and 4.68 (1.0-19.1), p = 0.001 and p = 0.032, respectively). These results demonstrate a rapid and sustained reduction in biomarkers of systemic inflammation under biologic treatment. Furthermore, these data suggest class-specific effects on systemic inflammation, which may be relevant for the prevention of psoriasis co-morbidity by systemic treatment. | ||
| 650 | 4 | |a adalimumab | |
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a cardiovascular disease | |
| 650 | 4 | |a etanercept | |
| 650 | 4 | |a psoriasis | |
| 650 | 4 | |a ustekinumab | |
| 700 | 1 | |a Knoop, Christian |d 1985- |e VerfasserIn |0 (DE-588)1077455364 |0 (DE-627)836709748 |0 (DE-576)446287903 |4 aut | |
| 700 | 1 | |a Enk, Alexander |d 1963- |e VerfasserIn |0 (DE-588)1032757140 |0 (DE-627)739272535 |0 (DE-576)166173517 |4 aut | |
| 700 | 1 | |a Hadaschik, Eva |e VerfasserIn |0 (DE-588)1054876916 |0 (DE-627)792376684 |0 (DE-576)410969842 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Acta dermato-venereologica |d Uppsala : Acta Dermato-Venereologica, 1921 |g 101(2021), 10, Artikel-ID adv00568, Seite 1-5 |h Online-Ressource |w (DE-627)302725431 |w (DE-600)1492617-9 |w (DE-576)081952848 |x 1651-2057 |7 nnas |a Detailed long-term dynamics of neutrophil-to-lymphocyte ratio under biologic treatment reveal differential effects of tumour necrosis factor-alpha and interleukin 12/23 antagonists |
| 773 | 1 | 8 | |g volume:101 |g year:2021 |g number:10 |g elocationid:adv00568 |g pages:1-5 |g extent:5 |a Detailed long-term dynamics of neutrophil-to-lymphocyte ratio under biologic treatment reveal differential effects of tumour necrosis factor-alpha and interleukin 12/23 antagonists |
| 856 | 4 | 0 | |u https://doi.org/10.2340/actadv.v101.271 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://medicaljournalssweden.se/actadv/article/view/271 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220404 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1054876916 |a Hadaschik, Eva |m 1054876916:Hadaschik, Eva |d 910000 |d 911300 |e 910000PH1054876916 |e 911300PH1054876916 |k 0/910000/ |k 1/910000/911300/ |p 4 |y j | ||
| 998 | |g 1032757140 |a Enk, Alexander |m 1032757140:Enk, Alexander |d 910000 |d 911300 |e 910000PE1032757140 |e 911300PE1032757140 |k 0/910000/ |k 1/910000/911300/ |p 3 | ||
| 998 | |g 1077455364 |a Knoop, Christian |m 1077455364:Knoop, Christian |d 910000 |d 950000 |d 950950 |e 910000PK1077455364 |e 950000PK1077455364 |e 950950PK1077455364 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 2 | ||
| 998 | |g 1074973267 |a Hoffmann, Jochen |m 1074973267:Hoffmann, Jochen |d 910000 |d 911300 |d 50000 |e 910000PH1074973267 |e 911300PH1074973267 |e 50000PH1074973267 |k 0/910000/ |k 1/910000/911300/ |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN179741156X |e 4111725619 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"Detailed long-term dynamics of neutrophil-to-lymphocyte ratio under biologic treatment reveal differential effects of tumour necrosis factor-alpha and interleukin 12/23 antagonists","title":"Detailed long-term dynamics of neutrophil-to-lymphocyte ratio under biologic treatment reveal differential effects of tumour necrosis factor-alpha and interleukin 12/23 antagonists"}],"note":["Gesehen am 06.04.2022"],"recId":"179741156X","relHost":[{"titleAlt":[{"title":"ActaDV"}],"part":{"year":"2021","extent":"5","pages":"1-5","volume":"101","text":"101(2021), 10, Artikel-ID adv00568, Seite 1-5","issue":"10"},"disp":"Detailed long-term dynamics of neutrophil-to-lymphocyte ratio under biologic treatment reveal differential effects of tumour necrosis factor-alpha and interleukin 12/23 antagonistsActa dermato-venereologica","language":["eng"],"title":[{"subtitle":"a journal for clinical and experimental research in the field of dermatology and venereology","title_sort":"Acta dermato-venereologica","title":"Acta dermato-venereologica"}],"note":["Fortsetzung der Druck-Ausgabe","Volltext auch als Teil einer Datenbank verfügbar","Gesehen am 16.10.24"],"pubHistory":["Volume 2, issue 2 (1921) [?]-"],"recId":"302725431","origin":[{"publisherPlace":"Uppsala ; Uppsala ; London [u.a.]","dateIssuedDisp":"[1921?]-","publisher":"Acta Dermato-Venereologica ; Medical Journals Sweden AB ; Taylor & Francis"}],"id":{"issn":["1651-2057"],"zdb":["1492617-9"],"eki":["302725431"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"role":"aut","given":"Jochen","display":"Hoffmann, Jochen","family":"Hoffmann"},{"family":"Knoop","display":"Knoop, Christian","given":"Christian","role":"aut"},{"family":"Enk","display":"Enk, Alexander","given":"Alexander","role":"aut"},{"display":"Hadaschik, Eva","family":"Hadaschik","role":"aut","given":"Eva"}],"name":{"displayForm":["Jochen H.O. Hoffmann, Christian Knoop, Alexander H. Enk and Eva N. Hadaschik"]},"id":{"doi":["10.2340/actadv.v101.271"],"eki":["179741156X"]},"physDesc":[{"extent":"5 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"Sep 30, 2021","dateIssuedKey":"2021"}]} | ||
| SRT | |a HOFFMANNJODETAILEDLO3020 | ||