Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment
Minimal residual disease (MRD) quantified after induction treatment of childhood acute lymphoblastic leukemia (ALL) predicts risk of relapse. It has been assumed that early relapses derive from a residual population of leukemic cells, which is still present after induction and that relapsed disease...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
06 May 2011
|
| In: |
Leukemia
Year: 2011, Jahrgang: 25, Heft: 8, Pages: 1305-1313 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/leu.2011.89 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/leu.2011.89 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/leu201189 
|
| Verfasserangaben: | C. Eckert, T. Flohr, R. Koehler, N. Hagedorn, A. Moericke, M. Stanulla, R. Kirschner-Schwabe, G. Cario, Av Stackelberg, C.R. Bartram, G. Henze, M. Schrappe and A. Schrauder |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1797453343 | ||
| 003 | DE-627 | ||
| 005 | 20220820160425.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220404s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/leu.2011.89 |2 doi | |
| 035 | |a (DE-627)1797453343 | ||
| 035 | |a (DE-599)KXP1797453343 | ||
| 035 | |a (OCoLC)1341458437 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Eckert, Cornelia |d 1971- |e VerfasserIn |0 (DE-588)128920998 |0 (DE-627)385334532 |0 (DE-576)297400290 |4 aut | |
| 245 | 1 | 0 | |a Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment |c C. Eckert, T. Flohr, R. Koehler, N. Hagedorn, A. Moericke, M. Stanulla, R. Kirschner-Schwabe, G. Cario, Av Stackelberg, C.R. Bartram, G. Henze, M. Schrappe and A. Schrauder |
| 264 | 1 | |c 06 May 2011 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.04.2022 | ||
| 520 | |a Minimal residual disease (MRD) quantified after induction treatment of childhood acute lymphoblastic leukemia (ALL) predicts risk of relapse. It has been assumed that early relapses derive from a residual population of leukemic cells, which is still present after induction and that relapsed disease will consequently be more resistant to treatment. To test these hypotheses, we performed a prospective study on patients treated according to the frontline-trial ALL-BFM 2000, which used MRD response for risk-group stratification. Patients (n=45) showed a median time to relapse of 1.5 years. In 89% of patients at least one T-cell-receptor/immunoglobulin gene rearrangement chosen for initial MRD quantification remained stable; however, at least one of the preferred markers for MRD stratification at relapse was different to diagnosis in 50% of patients. A similar proportion of very early, early and late relapses appeared to gain a marker at relapse although backtracking-analysis revealed that in 77% of cases, the gained markers were present as small sub-clones at initial diagnosis. Comparing initial and relapse MRD response to induction, 38% of patients showed a similar, 38% a better and 25% a poorer response after relapse. These data demonstrate an unexpectedly high clonal heterogeneity among very early/early relapses and challenge some current assumptions about relapsed ALL. | ||
| 650 | 4 | |a Acute lymphocytic leukaemia | |
| 650 | 4 | |a Cancer therapy | |
| 700 | 1 | |a Flohr, T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Köhler, Rolf |d 1966- |e VerfasserIn |0 (DE-588)12289751X |0 (DE-627)082221545 |0 (DE-576)293468427 |4 aut | |
| 700 | 1 | |a Hagedorn, N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Moericke, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stanulla, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kirschner-Schwabe, R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cario, G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stackelberg, Av |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bartram, Claus R. |d 1952- |e VerfasserIn |0 (DE-588)139758518 |0 (DE-627)613089502 |0 (DE-576)312997159 |4 aut | |
| 700 | 1 | |a Henze, G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schrappe, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schrauder, A. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Leukemia |d London : Springer Nature, 1997 |g 25(2011), 8, Seite 1305-1313 |h Online-Ressource |w (DE-627)32046699X |w (DE-600)2008023-2 |w (DE-576)094139733 |x 1476-5551 |7 nnas |a Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment |
| 773 | 1 | 8 | |g volume:25 |g year:2011 |g number:8 |g pages:1305-1313 |g extent:9 |a Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment |
| 856 | 4 | 0 | |u https://doi.org/10.1038/leu.2011.89 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/leu201189 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220404 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 139758518 |a Bartram, Claus R. |m 139758518:Bartram, Claus R. |d 910000 |d 911500 |e 910000PB139758518 |e 911500PB139758518 |k 0/910000/ |k 1/910000/911500/ |p 10 | ||
| 998 | |g 12289751X |a Köhler, Rolf |m 12289751X:Köhler, Rolf |d 910000 |d 911500 |e 910000PK12289751X |e 911500PK12289751X |k 0/910000/ |k 1/910000/911500/ |p 3 | ||
| 999 | |a KXP-PPN1797453343 |e 4111871844 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1038/leu.2011.89"],"eki":["1797453343"]},"origin":[{"dateIssuedDisp":"06 May 2011","dateIssuedKey":"2011"}],"name":{"displayForm":["C. Eckert, T. Flohr, R. Koehler, N. Hagedorn, A. Moericke, M. Stanulla, R. Kirschner-Schwabe, G. Cario, Av Stackelberg, C.R. Bartram, G. Henze, M. Schrappe and A. Schrauder"]},"recId":"1797453343","person":[{"family":"Eckert","given":"Cornelia","role":"aut","display":"Eckert, Cornelia"},{"display":"Flohr, T.","role":"aut","given":"T.","family":"Flohr"},{"display":"Köhler, Rolf","given":"Rolf","role":"aut","family":"Köhler"},{"given":"N.","role":"aut","family":"Hagedorn","display":"Hagedorn, N."},{"display":"Moericke, A.","given":"A.","role":"aut","family":"Moericke"},{"display":"Stanulla, M.","family":"Stanulla","given":"M.","role":"aut"},{"given":"R.","role":"aut","family":"Kirschner-Schwabe","display":"Kirschner-Schwabe, R."},{"display":"Cario, G.","role":"aut","given":"G.","family":"Cario"},{"family":"Stackelberg","role":"aut","given":"Av","display":"Stackelberg, Av"},{"given":"Claus R.","role":"aut","family":"Bartram","display":"Bartram, Claus R."},{"display":"Henze, G.","family":"Henze","given":"G.","role":"aut"},{"display":"Schrappe, M.","given":"M.","role":"aut","family":"Schrappe"},{"display":"Schrauder, A.","role":"aut","given":"A.","family":"Schrauder"}],"title":[{"title":"Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment","title_sort":"Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"physDesc":[{"extent":"9 S."}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 15.03.04"],"language":["eng"],"pubHistory":["Nachgewiesen 11.1997 -"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"subtitle":"normal and malignant hemopoiesis ; a peer-reviewed journal","title":"Leukemia","title_sort":"Leukemia"}],"recId":"32046699X","disp":"Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatmentLeukemia","id":{"issn":["1476-5551"],"zdb":["2008023-2"],"eki":["32046699X"]},"origin":[{"dateIssuedDisp":"1997-","dateIssuedKey":"1997","publisher":"Springer Nature ; Stockton Press ; Nature Publ. Group","publisherPlace":"London ; Basingstoke [u.a.] ; Basingstoke"}],"part":{"year":"2011","issue":"8","text":"25(2011), 8, Seite 1305-1313","extent":"9","pages":"1305-1313","volume":"25"}}],"note":["Gesehen am 04.04.2022"]} | ||
| SRT | |a ECKERTCORNVERYEARLYE0620 | ||