Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function
Amphotericin B is frequently used for the treatment of fungal infections of immunocompromised individuals. Whereas immunomodulatory side effects of this agent are known, the influence of amphotericin B was studied in the model of murine Listeria monocytogenes infection. Treatment of L. monocytogenes...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
8 September 1999
|
| In: |
The journal of infectious diseases
Year: 1999, Jahrgang: 180, Heft: 4, Pages: 1186-1194 |
| ISSN: | 1537-6613 |
| DOI: | 10.1086/315007 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1086/315007
|
| Verfasserangaben: | Gernot Geginat, Marianne Kretschmar, Simon Walter, Dieter Junker, Herbert Hof, Thomas Nichterlein |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1797736191 | ||
| 003 | DE-627 | ||
| 005 | 20230428015052.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220406s1999 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1086/315007 |2 doi | |
| 035 | |a (DE-627)1797736191 | ||
| 035 | |a (DE-599)KXP1797736191 | ||
| 035 | |a (OCoLC)1341458578 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Geginat, Gernot |e VerfasserIn |0 (DE-588)1050911725 |0 (DE-627)785281142 |0 (DE-576)40535553X |4 aut | |
| 245 | 1 | 0 | |a Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function |c Gernot Geginat, Marianne Kretschmar, Simon Walter, Dieter Junker, Herbert Hof, Thomas Nichterlein |
| 264 | 1 | |c 8 September 1999 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.04.2022 | ||
| 520 | |a Amphotericin B is frequently used for the treatment of fungal infections of immunocompromised individuals. Whereas immunomodulatory side effects of this agent are known, the influence of amphotericin B was studied in the model of murine Listeria monocytogenes infection. Treatment of L. monocytogenes-immune mice with a nontoxic dose of amphotericin B (0.75 mg/kg) reduced antilisterial protection by 4-5 orders of magnitude, while it had no significant effect on natural immunity against L. monocytogenes in naive mice. Treatment of mice with amphotericin B also abolished the protection mediated by transfer of an L. monocytogenes-specific CD8 T cell line. Furthermore, in vitro analysis showed that amphotericin B impaired target cell lysis and interferon-γ production by peptide-specific CD8 T cell lines and antigen presentation by L. monocytogenes-infected macrophagelike cells. These data indicate that amphotericin B has a strong suppressive effect on the function of CD8 T cells in vitro and in vivo. | ||
| 700 | 1 | |a Kretschmar, Marianne |e VerfasserIn |0 (DE-588)1079452680 |0 (DE-627)841134782 |0 (DE-576)182707873 |4 aut | |
| 700 | 1 | |a Walter, Simon |e VerfasserIn |0 (DE-588)1254958967 |0 (DE-627)1797734865 |4 aut | |
| 700 | 1 | |a Junker, Dieter |e VerfasserIn |0 (DE-588)1254959580 |0 (DE-627)1797735322 |4 aut | |
| 700 | 1 | |a Hof, Herbert |e VerfasserIn |0 (DE-588)1050912535 |0 (DE-627)785282548 |0 (DE-576)405358393 |4 aut | |
| 700 | 1 | |a Nichterlein, Thomas |e VerfasserIn |0 (DE-588)1104713403 |0 (DE-627)862075564 |0 (DE-576)178129712 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of infectious diseases |d Oxford [u.a.] : Oxford Univ. Press, 1904 |g 180(1999), 4, Seite 1186-1194 |h Online-Ressource |w (DE-627)269019294 |w (DE-600)1473843-0 |w (DE-576)077662784 |x 1537-6613 |7 nnas |a Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function |
| 773 | 1 | 8 | |g volume:180 |g year:1999 |g number:4 |g pages:1186-1194 |g extent:9 |a Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function |
| 856 | 4 | 0 | |u https://doi.org/10.1086/315007 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220406 | ||
| 994 | |a 1999 | ||
| 998 | |g 1104713403 |a Nichterlein, Thomas |m 1104713403:Nichterlein, Thomas |d 60000 |d 63200 |e 60000PN1104713403 |e 63200PN1104713403 |k 0/60000/ |k 1/60000/63200/ |p 6 |y j | ||
| 998 | |g 1050912535 |a Hof, Herbert |m 1050912535:Hof, Herbert |d 60000 |d 63200 |e 60000PH1050912535 |e 63200PH1050912535 |k 0/60000/ |k 1/60000/63200/ |p 5 | ||
| 998 | |g 1254959580 |a Junker, Dieter |m 1254959580:Junker, Dieter |d 60000 |d 63200 |e 60000PJ1254959580 |e 63200PJ1254959580 |k 0/60000/ |k 1/60000/63200/ |p 4 | ||
| 998 | |g 1254958967 |a Walter, Simon |m 1254958967:Walter, Simon |d 60000 |d 63200 |e 60000PW1254958967 |e 63200PW1254958967 |k 0/60000/ |k 1/60000/63200/ |p 3 | ||
| 998 | |g 1079452680 |a Kretschmar, Marianne |m 1079452680:Kretschmar, Marianne |d 60000 |d 63200 |e 60000PK1079452680 |e 63200PK1079452680 |k 0/60000/ |k 1/60000/63200/ |p 2 | ||
| 998 | |g 1050911725 |a Geginat, Gernot |m 1050911725:Geginat, Gernot |d 60000 |d 63200 |e 60000PG1050911725 |e 63200PG1050911725 |k 0/60000/ |k 1/60000/63200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1797736191 |e 4112375913 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 06.04.2022"],"language":["eng"],"recId":"1797736191","person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Geginat, Gernot","given":"Gernot","family":"Geginat"},{"given":"Marianne","family":"Kretschmar","role":"aut","roleDisplay":"VerfasserIn","display":"Kretschmar, Marianne"},{"given":"Simon","family":"Walter","role":"aut","display":"Walter, Simon","roleDisplay":"VerfasserIn"},{"given":"Dieter","family":"Junker","role":"aut","display":"Junker, Dieter","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Hof, Herbert","given":"Herbert","family":"Hof"},{"given":"Thomas","family":"Nichterlein","role":"aut","roleDisplay":"VerfasserIn","display":"Nichterlein, Thomas"}],"title":[{"title_sort":"Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function","title":"Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell function"}],"physDesc":[{"extent":"9 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["publ. for the John Rockefeller McCormick Memorial Fund of the University of Chicago. William H. Taliaferre, ed.-in-chief"]},"id":{"eki":["269019294"],"zdb":["1473843-0"],"issn":["1537-6613"]},"origin":[{"dateIssuedKey":"1904","publisher":"Oxford Univ. Press ; Univ. of Chicago Press","dateIssuedDisp":"1904-","publisherPlace":"Oxford [u.a.] ; Chicago, Ill."}],"recId":"269019294","language":["eng"],"note":["Gesehen am 01.03.11"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Suppression of acquired immunity against Listeria monocytogenes by amphotericin B$bmediated inhibition of CD8 T cell functionThe journal of infectious diseases","part":{"volume":"180","text":"180(1999), 4, Seite 1186-1194","extent":"9","year":"1999","pages":"1186-1194","issue":"4"},"pubHistory":["1.1904 -"],"title":[{"title_sort":"journal of infectious diseases","title":"The journal of infectious diseases","subtitle":"medical microbiology, clinical immunology, epidemiology"}]}],"name":{"displayForm":["Gernot Geginat, Marianne Kretschmar, Simon Walter, Dieter Junker, Herbert Hof, Thomas Nichterlein"]},"origin":[{"dateIssuedKey":"1999","dateIssuedDisp":"8 September 1999"}],"id":{"eki":["1797736191"],"doi":["10.1086/315007"]}} | ||
| SRT | |a GEGINATGERSUPPRESSIO8199 | ||