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Smoking modifies pancreatic cancer risk loci on 2q21.3

Germline variation and smoking are independently associated with pancreatic ductal adenocarcinoma (PDAC). We conducted genome-wide smoking interaction analysis of PDAC using genotype data from four previous genome-wide association studies in individuals of European ancestry (7,937 cases and 11,774 c...

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Main Authors: Mocci, Evelina (Author) , Kundu, Prosenjit (Author) , Wheeler, William (Author) , Arslan, Alan A. (Author) , Beane-Freeman, Laura E. (Author) , Bracci, Paige M. (Author) , Brennan, Paul (Author) , Canzian, Federico (Author) , Du, Mengmeng (Author) , Gallinger, Steven (Author) , Stolzenberg-Solomon, Rachael (Author)
Format: Article (Journal)
Language:English
Published: Februar 11, 2021
In: Cancer research
Year: 2021, Volume: 81, Issue: 11, Pages: 3134-3143
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-20-3267
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-20-3267
Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/cancerres/article/81/11/3134/673737/Smoking-Modifies-Pancreatic-Cancer-Risk-Loci-on
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Author Notes:Evelina Mocci, Prosenjit Kundu, William Wheeler, Alan A. Arslan, Laura E. Beane-Freeman, Paige M. Bracci, Paul Brennan, Federico Canzian, Mengmeng Du, Steven Gallinger, Graham G. Giles, Phyllis J. Goodman, Charles Kooperberg, Loic Le Marchand, Rachel E. Neale, Xiao-Ou Shu, Kala Visvanathan, Emily White, Wei Zheng, Demetrius Albanes, Gabriella Andreotti, Ana Babic, William R. Bamlet, Sonja I. Berndt, Amanda L. Blackford, Bas Bueno-de-Mesquita, Julie E. Buring, Daniele Campa, Stephen J. Chanock, Erica J. Childs, Eric J. Duell, Charles S. Fuchs, J. Michael Gaziano, Edward L. Giovannucci, Michael G. Goggins, Patricia Hartge, Manal M. Hassan, Elizabeth A. Holly, Robert N. Hoover, Rayjean J. Hung, Robert C. Kurtz, I-Min Lee, Núria Malats, Roger L. Milne, Kimmie Ng, Ann L. Oberg, Salvatore Panico, Ulrike Peters, Miquel Porta, Kari G. Rabe, Elio Riboli, Nathaniel Rothman, Ghislaine Scelo, Howard D. Sesso, Debra T. Silverman, Victoria L. Stevens, Oliver Strobel, Ian M., Jr Thompson, Anne Tjonneland, Antonia Trichopoulou, Stephen K. Van Den Eeden, Jean Wactawski-Wende, Nicolas Wentzensen, Lynne R. Wilkens, Herbert Yu, Fangcheng Yuan, Anne Zeleniuch-Jacquotte, Laufey T. Amundadottir, Donghui Li, Eric J. Jacobs, Gloria M. Petersen, Brian M. Wolpin, Harvey A. Risch, Peter Kraft, Nilanjan Chatterjee, Alison P. Klein, and Rachael Stolzenberg-Solomon
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Summary:Germline variation and smoking are independently associated with pancreatic ductal adenocarcinoma (PDAC). We conducted genome-wide smoking interaction analysis of PDAC using genotype data from four previous genome-wide association studies in individuals of European ancestry (7,937 cases and 11,774 controls).
Item Description:Gesehen am 07.04.2022
Physical Description:Online Resource
ISSN:1538-7445
DOI:10.1158/0008-5472.CAN-20-3267

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