Cover Image

Targeting cell cycle checkpoint kinases to overcome intrinsic radioresistance in brain tumor cells

Radiation therapy is an important part of the standard of care treatment of brain tumors. However, the efficacy of radiation therapy is limited by the radioresistance of tumor cells, a phenomenon held responsible for the dismal prognosis of the most aggressive brain tumor types. A promising approach...

Full description

Saved in:
Bibliographic Details
Main Authors: Vlatkovic, Tijana (Author) , Veldwijk, Marlon Romano (Author) , Giordano, Frank Anton (Author) , Herskind, Carsten (Author)
Format: Article (Journal)
Language:English
Published: 29 January 2022
In: Cancers
Year: 2022, Volume: 14, Issue: 3, Pages: 1-18
ISSN:2072-6694
DOI:10.3390/cancers14030701
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers14030701
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/14/3/701
Get full text
Author Notes:Tijana Vlatkovic, Marlon R. Veldwijk, Frank A. Giordano and Carsten Herskind

MARC

LEADER 00000caa a2200000 c 4500
001 1798241978
003 DE-627
005 20220820163358.0
007 cr uuu---uuuuu
008 220408s2022 xx |||||o 00| ||eng c
024 7 |a 10.3390/cancers14030701  |2 doi 
035 |a (DE-627)1798241978 
035 |a (DE-599)KXP1798241978 
035 |a (OCoLC)1341458858 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Vlatkovic, Tijana  |d 1981-  |e VerfasserIn  |0 (DE-588)125507728X  |0 (DE-627)1798241781  |4 aut 
245 1 0 |a Targeting cell cycle checkpoint kinases to overcome intrinsic radioresistance in brain tumor cells  |c Tijana Vlatkovic, Marlon R. Veldwijk, Frank A. Giordano and Carsten Herskind 
264 1 |c 29 January 2022 
300 |a 18 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 08.04.2022 
520 |a Radiation therapy is an important part of the standard of care treatment of brain tumors. However, the efficacy of radiation therapy is limited by the radioresistance of tumor cells, a phenomenon held responsible for the dismal prognosis of the most aggressive brain tumor types. A promising approach to radiosensitization of tumors is the inhibition of cell cycle checkpoint control responsible for cell cycle progression and the maintenance of genomic integrity. Inhibition of the kinases involved in these control mechanisms can abolish cell cycle checkpoints and DNA damage repair and thus increase the sensitivity of tumor cells to radiation and chemotherapy. Here, we discuss preclinical progress in molecular targeting of ATM, ATR, CHK1, CHK2, and WEE1, checkpoint kinases in the treatment of brain tumors, and review current clinical phase I-II trials. 
650 4 |a ATM 
650 4 |a ATR 
650 4 |a brain tumor 
650 4 |a cell cycle checkpoints 
650 4 |a checkpoint inhibitor 
650 4 |a CHK1 
650 4 |a CHK2 
650 4 |a radiation therapy 
650 4 |a radiosensitivity 
650 4 |a WEE1 
700 1 |a Veldwijk, Marlon Romano  |d 1973-  |e VerfasserIn  |0 (DE-588)124783562  |0 (DE-627)366051938  |0 (DE-576)294500278  |4 aut 
700 1 |a Giordano, Frank Anton  |d 1980-  |e VerfasserIn  |0 (DE-588)136378455  |0 (DE-627)694333093  |0 (DE-576)300990529  |4 aut 
700 1 |a Herskind, Carsten  |d 1952-  |e VerfasserIn  |0 (DE-588)1028380488  |0 (DE-627)730637409  |0 (DE-576)375919325  |4 aut 
773 0 8 |i Enthalten in  |t Cancers  |d Basel : MDPI, 2009  |g 14(2022), 3, Artikel-ID 701, Seite 1-18  |h Online-Ressource  |w (DE-627)614095670  |w (DE-600)2527080-1  |w (DE-576)313958548  |x 2072-6694  |7 nnas  |a Targeting cell cycle checkpoint kinases to overcome intrinsic radioresistance in brain tumor cells 
773 1 8 |g volume:14  |g year:2022  |g number:3  |g elocationid:701  |g pages:1-18  |g extent:18  |a Targeting cell cycle checkpoint kinases to overcome intrinsic radioresistance in brain tumor cells 
856 4 0 |u https://doi.org/10.3390/cancers14030701  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.mdpi.com/2072-6694/14/3/701  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20220517 
993 |a Article 
994 |a 2022 
998 |g 1028380488  |a Herskind, Carsten  |m 1028380488:Herskind, Carsten  |d 60000  |d 63000  |e 60000PH1028380488  |e 63000PH1028380488  |k 0/60000/  |k 1/60000/63000/  |p 4  |y j 
998 |g 136378455  |a Giordano, Frank Anton  |m 136378455:Giordano, Frank Anton  |d 60000  |d 63000  |e 60000PG136378455  |e 63000PG136378455  |k 0/60000/  |k 1/60000/63000/  |p 3 
998 |g 124783562  |a Veldwijk, Marlon Romano  |m 124783562:Veldwijk, Marlon Romano  |d 60000  |d 63000  |e 60000PV124783562  |e 63000PV124783562  |k 0/60000/  |k 1/60000/63000/  |p 2 
998 |g 125507728X  |a Vlatkovic, Tijana  |m 125507728X:Vlatkovic, Tijana  |d 60000  |d 63000  |e 60000PV125507728X  |e 63000PV125507728X  |k 0/60000/  |k 1/60000/63000/  |p 1  |x j 
999 |a KXP-PPN1798241978  |e 4135170013 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"language":["eng"],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"origin":[{"dateIssuedDisp":"2009-","publisher":"MDPI","dateIssuedKey":"2009","publisherPlace":"Basel"}],"title":[{"title":"Cancers","title_sort":"Cancers"}],"pubHistory":["1.2009 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2527080-1"],"eki":["614095670"],"issn":["2072-6694"]},"recId":"614095670","disp":"Targeting cell cycle checkpoint kinases to overcome intrinsic radioresistance in brain tumor cellsCancers","note":["Gesehen am 27.05.2020"],"part":{"text":"14(2022), 3, Artikel-ID 701, Seite 1-18","year":"2022","volume":"14","pages":"1-18","issue":"3","extent":"18"}}],"id":{"doi":["10.3390/cancers14030701"],"eki":["1798241978"]},"recId":"1798241978","physDesc":[{"extent":"18 S."}],"note":["Gesehen am 08.04.2022"],"name":{"displayForm":["Tijana Vlatkovic, Marlon R. Veldwijk, Frank A. Giordano and Carsten Herskind"]},"person":[{"display":"Vlatkovic, Tijana","role":"aut","given":"Tijana","family":"Vlatkovic"},{"display":"Veldwijk, Marlon Romano","family":"Veldwijk","given":"Marlon Romano","role":"aut"},{"display":"Giordano, Frank Anton","family":"Giordano","given":"Frank Anton","role":"aut"},{"role":"aut","given":"Carsten","family":"Herskind","display":"Herskind, Carsten"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Targeting cell cycle checkpoint kinases to overcome intrinsic radioresistance in brain tumor cells","title":"Targeting cell cycle checkpoint kinases to overcome intrinsic radioresistance in brain tumor cells"}],"origin":[{"dateIssuedDisp":"29 January 2022","dateIssuedKey":"2022"}]} 
SRT |a VLATKOVICTTARGETINGC2920 

Similar Items