Carbon ion radiotherapy performed as re-irradiation using active beam delivery in patients with tumors of the brain, skull base and sacral region
Introduction - To asses carbon ion radiation therapy (RT) performed as re-irradiation in 28 patients with recurrent tumors. - Materials and methods - Twenty-eight patients were treated with carbon ion RT as re-irradiation for recurrent chordoma and chondrosarcoma of the skull base (n=16 and n=2), on...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
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| In: |
Radiotherapy and oncology
Year: 2011, Volume: 98, Issue: 1, Pages: 63-67 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2010.10.010 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2010.10.010 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814010006055 
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| Author Notes: | Stephanie E. Combs, Adriana Kalbe, Anna Nikoghosyan, Benjamin Ackermann, Oliver Jäkel, Thomas Haberer, Jürgen Debus |
| Summary: | Introduction - To asses carbon ion radiation therapy (RT) performed as re-irradiation in 28 patients with recurrent tumors. - Materials and methods - Twenty-eight patients were treated with carbon ion RT as re-irradiation for recurrent chordoma and chondrosarcoma of the skull base (n=16 and n=2), one chordoma and one chondrosarcoma of the os sacrum, high-risk meningioma (n=3), adenoid-cystic carcinoma (n=4) as well as one SCCHN. All patients were treated using active raster scanning, and treatment planning was performed on CT- and MRI-basis. All patients were followed prospectively during follow-up. - Results - In all patients re-irradiation could be applied safely without interruptions. For skull base tumors, local tumor control after re-irradiation was 92% at 24months and 64% at 36months. Survival after re-irradiation was 86% at 24months, and 43% at 60months. In all three meningiomas treated with C12 for re-irradiation, the tumor recurrence was located within the former RT-field. Two patients developed tumor progression at 6months, and in one patient the tumor remained stable for 67months. In patients with head-and-neck tumors, three patients developed local tumor progression at 12, 24 and 29months after re-irradiation. Median local progression-free survival was 24months. For sacral tumors, re-irradiation offered palliation with tumor control for 24 and 36months. - Conclusion - Due to the physical characteristics particle therapy offers a new treatment modality in cases with tumor recurrences. With carbon ions, the additional biological benefits may be exploited for long-term tumor control. Further evaluation in a larger patients’ cohort will be performed in the future. |
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| Item Description: | Available online 25 November 2010 Gesehen am 08.04.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2010.10.010 |