The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel

Unraveling the relationship between genetic variation and phenotypic traits remains a fundamental challenge in biology. Mapping variants underlying complex traits while controlling for confounding environmental factors is often problematic. To address this, we establish a vertebrate genetic resource...

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Main Authors: Fitzgerald, Tomas (Author) , Brettell, Ian (Author) , Leger, Adrien (Author) , Wolf, Nadeshda (Author) , Kusminski, Natalja (Author) , Monahan, Jack (Author) , Barton, Carl (Author) , Herder, Cathrin (Author) , Aadepu, Narendar (Author) , Gierten, Jakob (Author) , Becker, Clara (Author) , Hammouda, Omar (Author) , Hasel, Eva Mareike (Author) , Lischik, Colin Q. (Author) , Lust, Katharina (Author) , Sokolova, Natalia (Author) , Suzuki, Risa (Author) , Tsingos, Erika (Author) , Tavhelidse-Suck, Tinatini (Author) , Thumberger, Thomas (Author) , Watson, Philip (Author) , Welz, Bettina (Author) , Khouja, Nadia (Author) , Naruse, Kiyoshi (Author) , Birney, Ewan (Author) , Wittbrodt, Joachim (Author) , Loosli, Felix (Author)
Format: Article (Journal)
Language:English
Published: 21 February 2022
In: Genome biology
Year: 2022, Volume: 23, Pages: 1-32
ISSN:1474-760X
DOI:10.1186/s13059-022-02623-z
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13059-022-02623-z
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Author Notes:Tomas Fitzgerald, Ian Brettell, Adrien Leger, Nadeshda Wolf, Natalja Kusminski, Jack Monahan, Carl Barton, Cathrin Herder, Narendar Aadepu, Jakob Gierten, Clara Becker, Omar T. Hammouda, Eva Hasel, Colin Lischik, Katharina Lust, Natalia Sokolova, Risa Suzuki, Erika Tsingos, Tinatini Tavhelidse, Thomas Thumberger, Philip Watson, Bettina Welz, Nadia Khouja, Kiyoshi Naruse, Ewan Birney, Joachim Wittbrodt and Felix Loosli
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Summary:Unraveling the relationship between genetic variation and phenotypic traits remains a fundamental challenge in biology. Mapping variants underlying complex traits while controlling for confounding environmental factors is often problematic. To address this, we establish a vertebrate genetic resource specifically to allow for robust genotype-to-phenotype investigations. The teleost medaka (Oryzias latipes) is an established genetic model system with a long history of genetic research and a high tolerance to inbreeding from the wild.
Item Description:Gesehen am 12.04.2022
Physical Description:Online Resource
ISSN:1474-760X
DOI:10.1186/s13059-022-02623-z