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The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective.

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Main Authors: Derrien, Jennifer (Author) , Guérin-Charbonnel, Catherine (Author) , Gaborit, Victor (Author) , Campion, Loïc (Author) , Devic, Magali (Author) , Douillard, Elise (Author) , Roi, Nathalie (Author) , Avet-Loiseau, Hervé (Author) , Decaux, Olivier (Author) , Facon, Thierry (Author) , Mallm, Jan-Philipp (Author) , Eils, Roland (Author) , Munshi, Nikhil C. (Author) , Moreau, Philippe (Author) , Herrmann, Carl (Author) , Magrangeas, Florence (Author) , Minvielle, Stéphane (Author)
Format: Article (Journal)
Language:English
Published: 09 August 2021
In: Genome medicine
Year: 2021, Volume: 13, Pages: 1-21
ISSN:1756-994X
DOI:10.1186/s13073-021-00938-3
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13073-021-00938-3
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Author Notes:Jennifer Derrien, Catherine Guérin-Charbonnel, Victor Gaborit, Loïc Campion, Magali Devic, Elise Douillard, Nathalie Roi, Hervé Avet-Loiseau, Olivier Decaux, Thierry Facon, Jan-Philipp Mallm, Roland Eils, Nikhil C. Munshi, Philippe Moreau, Carl Herrmann, Florence Magrangeas and Stéphane Minvielle

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