Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?
A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
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| In: |
Radiation oncology
Year: 2011, Jahrgang: 6, Pages: 1-5 |
| ISSN: | 1748-717X |
| DOI: | 10.1186/1748-717X-6-115 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1748-717X-6-115 Verlag, kostenfrei, Volltext: https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-6-115 
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| Verfasserangaben: | Stephanie E. Combs, Stefan Rieken, Wolfgang Wick, Amir Abdollahi, Andreas von Deimling, Jürgen Debus, and Christian Hartmann |
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| 520 | |a A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that methylation. IDH-1 mutations were significantly associated with increased overall survival. | ||
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