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Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: one step forward, and one step back?

A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free...

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Bibliographic Details
Main Authors: Combs, Stephanie (Author) , Rieken, Stefan (Author) , Wick, Wolfgang (Author) , Abdollahi, Amir (Author) , Deimling, Andreas von (Author) , Debus, Jürgen (Author) , Hartmann, Christian (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Radiation oncology
Year: 2011, Volume: 6, Pages: 1-5
ISSN:1748-717X
DOI:10.1186/1748-717X-6-115
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1748-717X-6-115
Verlag, kostenfrei, Volltext: https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-6-115
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Author Notes:Stephanie E. Combs, Stefan Rieken, Wolfgang Wick, Amir Abdollahi, Andreas von Deimling, Jürgen Debus, and Christian Hartmann
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Summary:A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that methylation. IDH-1 mutations were significantly associated with increased overall survival.
Item Description:Gesehen am 14.04.2022
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/1748-717X-6-115

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