Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers
Mutations in the BRCA1 gene substantially increase a woman's lifetime risk of breast cancer. However, there is great variation in this increase in risk with several genetic and non-genetic modifiers identified. The BRCA1 protein plays a central role in DNA repair, a mechanism that is particular...
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| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 2, 2011
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| In: |
Human molecular genetics
Year: 2011, Volume: 20, Issue: 23, Pages: 4732-4747 |
| ISSN: | 1460-2083 |
| DOI: | 10.1093/hmg/ddr388 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/hmg/ddr388 Verlag, kostenfrei, Volltext: https://academic.oup.com/hmg/article/20/23/4732/557410?login=true 
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| Author Notes: | David G. Cox, Ute Hamann, Christian Sutter, [und weitere] on behalf of the Consortium of Investigators of Modifiers of BRCA1/2 |
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Periungual fibroma (Koenen tumors) as isolated sign of tuberous sclerosis complex with tuberous sclerosis complex 1 germline mutation
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