Buchumschlag

TIMP-2 gene polymorphism is associated with intracerebral hemorrhage

BACKGROUND: Both ischemic stroke and intracerebral hemorrhage are associated with altered expression and activation of matrix metalloproteinases (MMPs). Particularly relevant are MMP-2 and MMP-9. This proteolytic effect is dampened by tissue inhibitors of metalloproteinases (TIMPs). TIMP-2 is an imp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Reuter, Björn (VerfasserIn) , Bugert, Peter (VerfasserIn) , Stroick, Mark Gregor (VerfasserIn) , Bukow, Simone (VerfasserIn) , Griebe, Martin (VerfasserIn) , Hennerici, Michael G. (VerfasserIn) , Fatar, Marc (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 16, 2009
In: Cerebrovascular diseases
Year: 2009, Jahrgang: 28, Heft: 6, Pages: 558-563
ISSN:1421-9786
DOI:10.1159/000247599
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000247599
Volltext
Verfasserangaben:Bjoern Reuter, Peter Bugert, Mark Stroick, Simone Bukow, Martin Griebe, Michael G. Hennerici, Marc Fatar

MARC

LEADER 00000caa a2200000 c 4500
001 1800055641
003 DE-627
005 20230427150858.0
007 cr uuu---uuuuu
008 220422s2009 xx |||||o 00| ||eng c
024 7 |a 10.1159/000247599  |2 doi 
035 |a (DE-627)1800055641 
035 |a (DE-599)KXP1800055641 
035 |a (OCoLC)1341459213 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Reuter, Björn  |d 1979-  |e VerfasserIn  |0 (DE-588)141344415  |0 (DE-627)626891361  |0 (DE-576)323197310  |4 aut 
245 1 0 |a TIMP-2 gene polymorphism is associated with intracerebral hemorrhage  |c Bjoern Reuter, Peter Bugert, Mark Stroick, Simone Bukow, Martin Griebe, Michael G. Hennerici, Marc Fatar 
264 1 |c October 16, 2009 
300 |a 6 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 22.04.2022 
520 |a BACKGROUND: Both ischemic stroke and intracerebral hemorrhage are associated with altered expression and activation of matrix metalloproteinases (MMPs). Particularly relevant are MMP-2 and MMP-9. This proteolytic effect is dampened by tissue inhibitors of metalloproteinases (TIMPs). TIMP-2 is an important endogenous inhibitor of MMP-2. Alterations in the TIMP-2 gene expression may contribute to the incidence of ischemic stroke and intracerebral hemorrhage. - METHODS: TIMP-2 gene SNP -261G/A was genotyped from sequentially recruited stroke patients (n = 356, f/m 151/205, mean age 68.2 years, range 19-100 years) and gender and age matched controls (n = 253, f/m 114/139, mean age 68.5 years, range 32-92 years). The SNP -261G/A was detected after gene sequencing of 95 patients and controls. Furthermore, in a subgroup of 93 patients the serum levels of TIMP-2 were measured during the first 7 days after stroke onset and compared to the genotype. - RESULTS: SNP -261G/A in the TIMP-2 gene shows an allele frequency of approximately 39.14%. Homozygosity for allele A is associated significantly with the development of ICH (p = 0.025, OR = 2.020, CI = 1.115-3.661) as compared to heterozygosity and homozygosity for allele G (recessive genotypic model). Concordantly, the serum levels of TIMP-2 showed a nonsignificant decreases, depending on the genotype (p = 0.111). - CONCLUSION: We investigated a SNP 261 base pairs upstream of the start codon in exon 1 of TIMP-2. Our data suggest that carriers of homozygosity for allele A are at increased risk of developing intracerebral hemorrhage. 
650 4 |a Adult 
650 4 |a Aged 
650 4 |a Aged, 80 and over 
650 4 |a Case-Control Studies 
650 4 |a Cerebral Hemorrhage 
650 4 |a Female 
650 4 |a Gene Frequency 
650 4 |a Genetic Predisposition to Disease 
650 4 |a Genotype 
650 4 |a Heterozygote 
650 4 |a Homozygote 
650 4 |a Humans 
650 4 |a Incidence 
650 4 |a Male 
650 4 |a Middle Aged 
650 4 |a Polymorphism, Single Nucleotide 
650 4 |a Tissue Inhibitor of Metalloproteinase-2 
700 1 |a Bugert, Peter  |d 1964-  |e VerfasserIn  |0 (DE-588)1025332342  |0 (DE-627)722074018  |0 (DE-576)370212169  |4 aut 
700 1 |a Stroick, Mark Gregor  |d 1974-  |e VerfasserIn  |0 (DE-588)124641946  |0 (DE-627)575608684  |0 (DE-576)294426094  |4 aut 
700 1 |a Bukow, Simone  |e VerfasserIn  |0 (DE-588)1257106678  |0 (DE-627)1801206627  |4 aut 
700 1 |a Griebe, Martin  |d 1975-  |e VerfasserIn  |0 (DE-588)132614006  |0 (DE-627)524422168  |0 (DE-576)299257452  |4 aut 
700 1 |a Hennerici, Michael G.  |d 1948-  |e VerfasserIn  |0 (DE-588)11587545X  |0 (DE-627)077527704  |0 (DE-576)290126444  |4 aut 
700 1 |a Fatar, Marc  |d 1972-  |e VerfasserIn  |0 (DE-588)12250108X  |0 (DE-627)705931501  |0 (DE-576)293298963  |4 aut 
773 0 8 |i Enthalten in  |t Cerebrovascular diseases  |d Basel : Karger, 1991  |g 28(2009), 6, Seite 558-563  |h Online-Ressource  |w (DE-627)300189834  |w (DE-600)1482069-9  |w (DE-576)097267651  |x 1421-9786  |7 nnas  |a TIMP-2 gene polymorphism is associated with intracerebral hemorrhage 
773 1 8 |g volume:28  |g year:2009  |g number:6  |g pages:558-563  |g extent:6  |a TIMP-2 gene polymorphism is associated with intracerebral hemorrhage 
856 4 0 |u https://doi.org/10.1159/000247599  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20220422 
993 |a Article 
994 |a 2009 
998 |g 12250108X  |a Fatar, Marc  |m 12250108X:Fatar, Marc  |d 60000  |d 62700  |e 60000PF12250108X  |e 62700PF12250108X  |k 0/60000/  |k 1/60000/62700/  |p 7  |y j 
998 |g 11587545X  |a Hennerici, Michael G.  |m 11587545X:Hennerici, Michael G.  |d 60000  |d 62700  |d 60000  |e 60000PH11587545X  |e 62700PH11587545X  |e 60000PH11587545X  |k 0/60000/  |k 1/60000/62700/  |k 0/60000/  |p 6 
998 |g 132614006  |a Griebe, Martin  |m 132614006:Griebe, Martin  |d 60000  |d 62700  |e 60000PG132614006  |e 62700PG132614006  |k 0/60000/  |k 1/60000/62700/  |p 5 
998 |g 1257106678  |a Bukow, Simone  |m 1257106678:Bukow, Simone  |d 60000  |d 62700  |e 60000PB1257106678  |e 62700PB1257106678  |k 0/60000/  |k 1/60000/62700/  |p 4 
998 |g 124641946  |a Stroick, Mark Gregor  |m 124641946:Stroick, Mark Gregor  |d 60000  |d 62700  |e 60000PS124641946  |e 62700PS124641946  |k 0/60000/  |k 1/60000/62700/  |p 3 
998 |g 1025332342  |a Bugert, Peter  |m 1025332342:Bugert, Peter  |d 60000  |d 63500  |e 60000PB1025332342  |e 63500PB1025332342  |k 0/60000/  |k 1/60000/63500/  |p 2 
998 |g 141344415  |a Reuter, Björn  |m 141344415:Reuter, Björn  |d 60000  |e 60000PR141344415  |k 0/60000/  |p 1  |x j 
999 |a KXP-PPN1800055641  |e 4120152197 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"title":[{"title_sort":"TIMP-2 gene polymorphism is associated with intracerebral hemorrhage","title":"TIMP-2 gene polymorphism is associated with intracerebral hemorrhage"}],"relHost":[{"recId":"300189834","id":{"zdb":["1482069-9"],"issn":["1421-9786"],"eki":["300189834"]},"pubHistory":["1.1991 -"],"note":["Gesehen am 08.01.2019","Ungezählte Beil.: Supplement"],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1991-","dateIssuedKey":"1991","publisherPlace":"Basel","publisher":"Karger"}],"title":[{"title_sort":"Cerebrovascular diseases","title":"Cerebrovascular diseases"}],"language":["eng"],"disp":"TIMP-2 gene polymorphism is associated with intracerebral hemorrhageCerebrovascular diseases","part":{"issue":"6","year":"2009","extent":"6","pages":"558-563","volume":"28","text":"28(2009), 6, Seite 558-563"},"type":{"bibl":"periodical","media":"Online-Ressource"}}],"origin":[{"dateIssuedKey":"2009","dateIssuedDisp":"October 16, 2009"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1800055641"],"doi":["10.1159/000247599"]},"recId":"1800055641","name":{"displayForm":["Bjoern Reuter, Peter Bugert, Mark Stroick, Simone Bukow, Martin Griebe, Michael G. Hennerici, Marc Fatar"]},"person":[{"given":"Björn","family":"Reuter","role":"aut","display":"Reuter, Björn","roleDisplay":"VerfasserIn"},{"given":"Peter","family":"Bugert","roleDisplay":"VerfasserIn","display":"Bugert, Peter","role":"aut"},{"family":"Stroick","given":"Mark Gregor","roleDisplay":"VerfasserIn","display":"Stroick, Mark Gregor","role":"aut"},{"family":"Bukow","given":"Simone","display":"Bukow, Simone","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Martin","family":"Griebe","display":"Griebe, Martin","role":"aut","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Hennerici, Michael G.","roleDisplay":"VerfasserIn","given":"Michael G.","family":"Hennerici"},{"given":"Marc","family":"Fatar","roleDisplay":"VerfasserIn","display":"Fatar, Marc","role":"aut"}],"physDesc":[{"extent":"6 S."}],"note":["Gesehen am 22.04.2022"]} 
SRT |a REUTERBJOETIMP2GENEP1620 

Ähnliche Einträge