The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets
Cellular life depends on a complex web of functional associations between biomolecules. Among these associations, protein-protein interactions are particularly important due to their versatility, specificity and adaptability. The STRING database aims to integrate all known and predicted associations...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
|
| In: |
Nucleic acids research
Year: 2021, Jahrgang: 49, Heft: D1, Pages: D605-D612 |
| ISSN: | 1362-4962 |
| DOI: | 10.1093/nar/gkaa1074 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/nar/gkaa1074
|
| Verfasserangaben: | Damian Szklarczyk, Annika L. Gable, Katerina C. Nastou, David Lyon, Rebecca Kirsch, Sampo Pyysalo, Nadezhda T. Doncheva, Marc Legeay, Tao Fang, Peer Bork, Lars J. Jensen and Christian von Mering |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1800076894 | ||
| 003 | DE-627 | ||
| 005 | 20220820170941.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220423s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/nar/gkaa1074 |2 doi | |
| 035 | |a (DE-627)1800076894 | ||
| 035 | |a (DE-599)KXP1800076894 | ||
| 035 | |a (OCoLC)1341459074 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Szklarczyk, Damian |e VerfasserIn |0 (DE-588)1161631402 |0 (DE-627)1024926087 |0 (DE-576)506784495 |4 aut | |
| 245 | 1 | 4 | |a The STRING database in 2021 |b customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets |c Damian Szklarczyk, Annika L. Gable, Katerina C. Nastou, David Lyon, Rebecca Kirsch, Sampo Pyysalo, Nadezhda T. Doncheva, Marc Legeay, Tao Fang, Peer Bork, Lars J. Jensen and Christian von Mering |
| 264 | 1 | |c 2021 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online Publikationsdatum: 25 November 2020 | ||
| 500 | |a Gesehen am 23.04.2022 | ||
| 520 | |a Cellular life depends on a complex web of functional associations between biomolecules. Among these associations, protein-protein interactions are particularly important due to their versatility, specificity and adaptability. The STRING database aims to integrate all known and predicted associations between proteins, including both physical interactions as well as functional associations. To achieve this, STRING collects and scores evidence from a number of sources: (i) automated text mining of the scientific literature, (ii) databases of interaction experiments and annotated complexes/pathways, (iii) computational interaction predictions from co-expression and from conserved genomic context and (iv) systematic transfers of interaction evidence from one organism to another. STRING aims for wide coverage; the upcoming version 11.5 of the resource will contain more than 14 000 organisms. In this update paper, we describe changes to the text-mining system, a new scoring-mode for physical interactions, as well as extensive user interface features for customizing, extending and sharing protein networks. In addition, we describe how to query STRING with genome-wide, experimental data, including the automated detection of enriched functionalities and potential biases in the user's query data. The STRING resource is available online, at https://string-db.org/. | ||
| 700 | 1 | |a Gable, Annika L |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nastou, Katerina C |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lyon, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kirsch, Rebecca |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pyysalo, Sampo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Doncheva, Nadezhda T |e VerfasserIn |4 aut | |
| 700 | 1 | |a Legeay, Marc |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fang, Tao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bork, Peer |d 1963- |e VerfasserIn |0 (DE-588)122539117 |0 (DE-627)705944476 |0 (DE-576)293313946 |4 aut | |
| 700 | 1 | |a Jensen, Lars J |e VerfasserIn |4 aut | |
| 700 | 1 | |a von Mering, Christian |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nucleic acids research |d Oxford : Oxford Univ. Press, 1974 |g 49(2021), D1, Seite D605-D612 |h Online-Ressource |w (DE-627)26813250X |w (DE-600)1472175-2 |w (DE-576)07760878X |x 1362-4962 |7 nnas |a The STRING database in 2021 customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets |
| 773 | 1 | 8 | |g volume:49 |g year:2021 |g number:D1 |g pages:D605-D612 |g extent:8 |a The STRING database in 2021 customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets |
| 856 | 4 | 0 | |u https://doi.org/10.1093/nar/gkaa1074 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220423 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 122539117 |a Bork, Peer |m 122539117:Bork, Peer |d 140000 |e 140000PB122539117 |k 0/140000/ |p 10 | ||
| 999 | |a KXP-PPN1800076894 |e 4120291227 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1800076894","note":["Online Publikationsdatum: 25 November 2020","Gesehen am 23.04.2022"],"language":["eng"],"person":[{"family":"Szklarczyk","display":"Szklarczyk, Damian","roleDisplay":"VerfasserIn","role":"aut","given":"Damian"},{"family":"Gable","display":"Gable, Annika L","role":"aut","roleDisplay":"VerfasserIn","given":"Annika L"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Katerina C","display":"Nastou, Katerina C","family":"Nastou"},{"display":"Lyon, David","given":"David","roleDisplay":"VerfasserIn","role":"aut","family":"Lyon"},{"family":"Kirsch","given":"Rebecca","role":"aut","roleDisplay":"VerfasserIn","display":"Kirsch, Rebecca"},{"given":"Sampo","role":"aut","roleDisplay":"VerfasserIn","display":"Pyysalo, Sampo","family":"Pyysalo"},{"family":"Doncheva","display":"Doncheva, Nadezhda T","given":"Nadezhda T","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Legeay","given":"Marc","role":"aut","roleDisplay":"VerfasserIn","display":"Legeay, Marc"},{"display":"Fang, Tao","roleDisplay":"VerfasserIn","role":"aut","given":"Tao","family":"Fang"},{"given":"Peer","role":"aut","roleDisplay":"VerfasserIn","display":"Bork, Peer","family":"Bork"},{"family":"Jensen","role":"aut","roleDisplay":"VerfasserIn","given":"Lars J","display":"Jensen, Lars J"},{"family":"von Mering","role":"aut","roleDisplay":"VerfasserIn","given":"Christian","display":"von Mering, Christian"}],"relHost":[{"id":{"issn":["1362-4962"],"zdb":["1472175-2"],"eki":["26813250X"]},"titleAlt":[{"title":"NAR online"},{"title":"NAR"},{"title":"Database issue"},{"title":"Web server issue"}],"note":["Gesehen am 15.09.2025","Ungezählte Beil.: Database issue; Web server issue"],"part":{"issue":"D1","volume":"49","year":"2021","extent":"8","pages":"D605-D612","text":"49(2021), D1, Seite D605-D612"},"recId":"26813250X","pubHistory":["1.1974 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title_sort":"Nucleic acids research","title":"Nucleic acids research"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1974-","publisher":"Oxford Univ. Press","dateIssuedKey":"1974","publisherPlace":"Oxford"}],"language":["eng"],"disp":"The STRING database in 2021 customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement setsNucleic acids research"}],"name":{"displayForm":["Damian Szklarczyk, Annika L. Gable, Katerina C. Nastou, David Lyon, Rebecca Kirsch, Sampo Pyysalo, Nadezhda T. Doncheva, Marc Legeay, Tao Fang, Peer Bork, Lars J. Jensen and Christian von Mering"]},"origin":[{"dateIssuedDisp":"2021","dateIssuedKey":"2021"}],"id":{"eki":["1800076894"],"doi":["10.1093/nar/gkaa1074"]},"physDesc":[{"extent":"8 S."}],"title":[{"subtitle":"customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets","title_sort":"STRING database in 2021","title":"The STRING database in 2021"}]} | ||
| SRT | |a SZKLARCZYKSTRINGDATA2021 | ||