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PROX1 is a predictor of survival for gliomas WHO grade II

The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a tr...

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Main Authors: Elsir, Tamador (Author) , Qu, M. (Author) , Berntsson, S. G. (Author) , Orrego, A. (Author) , Olofsson, T. (Author) , Lindström, M. S. (Author) , Nistér, M. (Author) , Deimling, Andreas von (Author) , Hartmann, Christian (Author) , Ribom, D. (Author) , Smits, A. (Author)
Format: Article (Journal)
Language:English
Published: 10 May 2011
In: British journal of cancer
Year: 2011, Volume: 104, Issue: 11, Pages: 1747-1754
ISSN:1532-1827
DOI:10.1038/bjc.2011.162
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bjc.2011.162
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bjc2011162
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Author Notes:T. Elsir, M. Qu, S.G. Berntsson, A. Orrego, T. Olofsson, M.S. Lindström, M. Nistér, A. von Deimling, C. Hartmann, D. Ribom and A. Smits

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520 |a The clinical course of World Health Organisation grade II gliomas remains variable and their time point of transformation into a more malignant phenotype is unpredictable. Identification of biological markers that can predict prognosis in individual patients is of great clinical value. PROX1 is a transcription factor that has a critical role in the development of various organs. PROX1 has been ascribed both oncogenic and tumour suppressive functions in human cancers. We have recently shown that PROX1 may act as a diagnostic marker for high-grade gliomas. The aim of this study was to address the prognostic value of PROX1 in grade II gliomas. 
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