Infrared spectroscopy: a new diagnostic tool in Alzheimer disease
Biological markers play an evolving role in the diagnosis of Alzheimer disease (AD). We compare conventional measurements of cerebrospinal fluid (CSF) tau and beta-amyloid(1-42) proteins to a novel approach - Fourier transformed infrared (FT-IR) spectroscopy - a simple technique derived from chemica...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 May 2007
|
| In: |
Neuroscience letters
Year: 2007, Jahrgang: 420, Heft: 1, Pages: 29-33 |
| ISSN: | 1872-7972 |
| DOI: | 10.1016/j.neulet.2007.03.075 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neulet.2007.03.075
|
| Verfasserangaben: | Martin Griebe, Michael Daffertshofer, Mark Stroick, Magdalena Syren, Parviz Ahmad-Nejad, Michael Neumaier, Juergen Backhaus, Michael G. Hennerici, Marc Fatar |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1800631081 | ||
| 003 | DE-627 | ||
| 005 | 20220820173418.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220502s2007 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.neulet.2007.03.075 |2 doi | |
| 035 | |a (DE-627)1800631081 | ||
| 035 | |a (DE-599)KXP1800631081 | ||
| 035 | |a (OCoLC)1341459315 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Griebe, Martin |d 1975- |e VerfasserIn |0 (DE-588)132614006 |0 (DE-627)524422168 |0 (DE-576)299257452 |4 aut | |
| 245 | 1 | 0 | |a Infrared spectroscopy |b a new diagnostic tool in Alzheimer disease |c Martin Griebe, Michael Daffertshofer, Mark Stroick, Magdalena Syren, Parviz Ahmad-Nejad, Michael Neumaier, Juergen Backhaus, Michael G. Hennerici, Marc Fatar |
| 264 | 1 | |c 4 May 2007 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.05.2022 | ||
| 520 | |a Biological markers play an evolving role in the diagnosis of Alzheimer disease (AD). We compare conventional measurements of cerebrospinal fluid (CSF) tau and beta-amyloid(1-42) proteins to a novel approach - Fourier transformed infrared (FT-IR) spectroscopy - a simple technique derived from chemical and physical sciences that characterizes intramolecular bonds. For automatic diagnostic analysis, we developed an artificial neural network (ANN). We examined 71 patients with a clinical diagnosis of AD and 66 controls. beta-Amyloid(1-42) was decreased (sensitivity 80% and specificity 78%); tau was elevated (sensitivity 76% and specificity 88%) in CSF of AD patients. The combined tau/beta-amyloid(1-42) quotient was able to distinguish healthy from diseased subjects with 99% sensitivity and 86% specificity. The ANN could separate FT-IR spectroscopy data with 88.5% sensitivity and 80% specificity. FT-IR spectroscopy proved to be cost-effective and simple to perform. Diagnostic sensitivity and specificity is in the range of CSF tau and beta-amyloid(1-42) protein analysis. Larger sample numbers for ANN training and validation could increase diagnostic accuracy and thus prove to be a useful screening tool. | ||
| 650 | 4 | |a Adolescent | |
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Aged, 80 and over | |
| 650 | 4 | |a Alzheimer Disease | |
| 650 | 4 | |a Amyloid beta-Peptides | |
| 650 | 4 | |a Analysis of Variance | |
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Neural Networks, Computer | |
| 650 | 4 | |a Neuropsychological Tests | |
| 650 | 4 | |a Peptide Fragments | |
| 650 | 4 | |a Spectrophotometry, Infrared | |
| 650 | 4 | |a Spectroscopy, Fourier Transform Infrared | |
| 650 | 4 | |a tau Proteins | |
| 650 | 4 | |a Young Adult | |
| 700 | 1 | |a Daffertshofer, Michael |e VerfasserIn |0 (DE-588)1206109661 |0 (DE-627)1691876909 |4 aut | |
| 700 | 1 | |a Stroick, Mark Gregor |d 1974- |e VerfasserIn |0 (DE-588)124641946 |0 (DE-627)575608684 |0 (DE-576)294426094 |4 aut | |
| 700 | 1 | |a Syren, Magdalena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ahmad-Nejad, Parviz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Neumaier, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Backhaus, Jürgen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hennerici, Michael G. |d 1948- |e VerfasserIn |0 (DE-588)11587545X |0 (DE-627)077527704 |0 (DE-576)290126444 |4 aut | |
| 700 | 1 | |a Fatar, Marc |d 1972- |e VerfasserIn |0 (DE-588)12250108X |0 (DE-627)705931501 |0 (DE-576)293298963 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuroscience letters |d Amsterdam [u.a.] : Elsevier Science, 1975 |g 420(2007), 1, Seite 29-33 |h Online-Ressource |w (DE-627)306589699 |w (DE-600)1498535-4 |w (DE-576)081953119 |x 1872-7972 |7 nnas |a Infrared spectroscopy a new diagnostic tool in Alzheimer disease |
| 773 | 1 | 8 | |g volume:420 |g year:2007 |g number:1 |g pages:29-33 |g extent:5 |a Infrared spectroscopy a new diagnostic tool in Alzheimer disease |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.neulet.2007.03.075 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220502 | ||
| 993 | |a Article | ||
| 994 | |a 2007 | ||
| 998 | |g 12250108X |a Fatar, Marc |m 12250108X:Fatar, Marc |d 60000 |d 62700 |e 60000PF12250108X |e 62700PF12250108X |k 0/60000/ |k 1/60000/62700/ |p 9 |y j | ||
| 998 | |g 11587545X |a Hennerici, Michael G. |m 11587545X:Hennerici, Michael G. |d 60000 |d 62700 |d 60000 |e 60000PH11587545X |e 62700PH11587545X |e 60000PH11587545X |k 0/60000/ |k 1/60000/62700/ |k 0/60000/ |p 8 | ||
| 998 | |g 124641946 |a Stroick, Mark Gregor |m 124641946:Stroick, Mark Gregor |d 60000 |d 62700 |e 60000PS124641946 |e 62700PS124641946 |k 0/60000/ |k 1/60000/62700/ |p 3 | ||
| 998 | |g 1206109661 |a Daffertshofer, Michael |m 1206109661:Daffertshofer, Michael |d 60000 |e 60000PD1206109661 |k 0/60000/ |p 2 | ||
| 998 | |g 132614006 |a Griebe, Martin |m 132614006:Griebe, Martin |d 60000 |d 62700 |e 60000PG132614006 |e 62700PG132614006 |k 0/60000/ |k 1/60000/62700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1800631081 |e 4128045209 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1800631081","language":["eng"],"note":["Gesehen am 02.05.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"subtitle":"a new diagnostic tool in Alzheimer disease","title":"Infrared spectroscopy","title_sort":"Infrared spectroscopy"}],"person":[{"given":"Martin","family":"Griebe","role":"aut","roleDisplay":"VerfasserIn","display":"Griebe, Martin"},{"given":"Michael","family":"Daffertshofer","role":"aut","roleDisplay":"VerfasserIn","display":"Daffertshofer, Michael"},{"given":"Mark Gregor","family":"Stroick","role":"aut","display":"Stroick, Mark Gregor","roleDisplay":"VerfasserIn"},{"family":"Syren","given":"Magdalena","roleDisplay":"VerfasserIn","display":"Syren, Magdalena","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Ahmad-Nejad, Parviz","role":"aut","family":"Ahmad-Nejad","given":"Parviz"},{"given":"Michael","family":"Neumaier","role":"aut","display":"Neumaier, Michael","roleDisplay":"VerfasserIn"},{"display":"Backhaus, Jürgen","roleDisplay":"VerfasserIn","role":"aut","family":"Backhaus","given":"Jürgen"},{"given":"Michael G.","family":"Hennerici","role":"aut","roleDisplay":"VerfasserIn","display":"Hennerici, Michael G."},{"given":"Marc","family":"Fatar","role":"aut","display":"Fatar, Marc","roleDisplay":"VerfasserIn"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1975-","publisher":"Elsevier Science","dateIssuedKey":"1975"}],"id":{"issn":["1872-7972"],"zdb":["1498535-4"],"eki":["306589699"]},"disp":"Infrared spectroscopy a new diagnostic tool in Alzheimer diseaseNeuroscience letters","note":["Gesehen am 20.02.20","Ungezählte Beil.: Supplement"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"306589699","language":["eng"],"pubHistory":["1.1975 -"],"part":{"issue":"1","pages":"29-33","year":"2007","extent":"5","volume":"420","text":"420(2007), 1, Seite 29-33"},"title":[{"title_sort":"Neuroscience letters","subtitle":"an international multidisciplinary journal devoted to the rapid publication of basic research in the neurosciences","title":"Neuroscience letters"}]}],"physDesc":[{"extent":"5 S."}],"id":{"doi":["10.1016/j.neulet.2007.03.075"],"eki":["1800631081"]},"origin":[{"dateIssuedDisp":"4 May 2007","dateIssuedKey":"2007"}],"name":{"displayForm":["Martin Griebe, Michael Daffertshofer, Mark Stroick, Magdalena Syren, Parviz Ahmad-Nejad, Michael Neumaier, Juergen Backhaus, Michael G. Hennerici, Marc Fatar"]}} | ||
| SRT | |a GRIEBEMARTINFRAREDSP4200 | ||