Pivotal antitumor role of the immune checkpoint molecule B7-H1 in pancreatic cancer
Immune checkpoint molecule B7-H1 plays a decisive immune regulatory role in different pathologies including cancer, and manipulation of B7-H1 expression became an attractive approach in cancer immunotherapy. Pancreatic cancer (PDAC) is characterized by pronounced immunosuppressive environment and B7...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 Mar 2022
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| In: |
OncoImmunology
Year: 2022, Volume: 11, Issue: 1, Pages: 1-14 |
| ISSN: | 2162-402X |
| DOI: | 10.1080/2162402X.2022.2043037 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/2162402X.2022.2043037
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| Author Notes: | Alexandr V. Bazhin, Katharina von Ahn, Jasmin Fritz, Henriette Bunge, Caroline Maier, Orkhan Isayev, Florian Neff, Jens T. Siveke & Svetlana Karakhanova |
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| 520 | |a Immune checkpoint molecule B7-H1 plays a decisive immune regulatory role in different pathologies including cancer, and manipulation of B7-H1 expression became an attractive approach in cancer immunotherapy. Pancreatic cancer (PDAC) is characterized by pronounced immunosuppressive environment and B7-H1 expression correlates with PDAC prognosis. However, the first attempts to diminish B7-H1 expression in patients were not so successful. This points the complicity of PDAC immunosuppressive network and requires further examinations. We investigated the effect of B7-H1 deficiency in PDAC. Our results clearly show that partial or complete B7-H1 inhibition in vivo let to reduced tumor volume and improved survival of PDAC-bearing mice. This oncological benefit is due to the abrogation of immunosuppression provided by MDSC, macrophages, DC and Treg, which resulted in simultaneous restoration of anti-tumor immune response, namely improved accumulation and functionality of effector-memory CD4 and CD8 T cells. Our results underline the potential of B7-H1 molecule to control immunosuppressive network in PDAC and provide new issues for further clinical investigations. | ||
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