Poorly differentiated small cell carcinoma of the pancreas: a case report and review of the literature

Small cell carcinoma (SCC) of the pancreas is a rare malignancy with an extremely poor prognosis. We present the case of a 74-year-old man with a 2-month history of upper abdominal discomfort who was diagnosed with SCC of the pancreas tail, involvement of peri-pancreatic and mesenteric lymph nodes a...

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Main Authors: Berkel, Simone (Author) , Hummel, Frank (Author) , Gaa, Jochen (Author) , Back, Walter (Author) , Hofheinz, Ralf-Dieter (Author) , Queißer, Wolfgang (Author) , Singer, Manfred V. (Author) , Löhr, J.-Matthias (Author)
Format: Article (Journal)
Language:English
Published: August 27, 2004
In: Pancreatology
Year: 2004, Volume: 4, Issue: 6, Pages: 521-526
ISSN:1424-3911
DOI:10.1159/000080526
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000080526
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1424390304800383
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Author Notes:Simone Berkel, Frank Hummel, Jochen Gaa, Walter Back, Ralf Hofheinz, Wolfgang Queisser, Manfred V. Singer, Matthias Löhr

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520 |a Small cell carcinoma (SCC) of the pancreas is a rare malignancy with an extremely poor prognosis. We present the case of a 74-year-old man with a 2-month history of upper abdominal discomfort who was diagnosed with SCC of the pancreas tail, involvement of peri-pancreatic and mesenteric lymph nodes and multiple liver metastases (extended disease). A CT scan and a positive somatostatin receptor scintigraphy showed no evidence of a primary lung tumour. The diagnosis of a SCC was confirmed by biopsy. Local tumour control could be achieved by gemcitabine once a week and a long-acting somatostatin analogue once a month, but liver metastasis showed progress. Thus, 5-fluorouracil on a weekly basis was started. The patient died 8 months after diagnosis and had not been hospitalised in the meantime. 
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